(Q46507878)

English

Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation

scientific article published on 2 July 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

0 references

0 references

4

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

author name string

Laura Gray

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

Maarten van den Buuse

2

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

Elizabeth Scarr

3

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

Anthony J Hannan

5

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

publication date

2 July 2008

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

The International Journal of Neuropsychopharmacology

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

12

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

45-60

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

To model a psychiatric disorder in animals: schizophrenia as a reality test

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Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade

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Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia

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Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?

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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

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NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

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Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents

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Glutamate as a therapeutic target in psychiatric disorders

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Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex

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The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

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Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol

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The neuropathology of schizophrenia. A critical review of the data and their interpretation

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PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

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Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia

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Neurotransmission- and cellular stress-related gene expression associated with prepulse inhibition in mice

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Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning

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Functional and anatomical aspects of prefrontal pathology in schizophrenia

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Effect of chronic clozapine administration on [3H]MK801-binding sites in the rat brain: a side-preference action in cortical areas.

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Metabotropic glutamate receptors are involved in amygdaloid plasticity

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Molecular morphogens for dendritic spines

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Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function

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21 January 2018

The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia

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Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder

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A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons.

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Glutamate and schizophrenia: beyond the dopamine hypothesis

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Prefrontal neurons and the genetics of schizophrenia

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

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Enhanced effect of dopaminergic stimulation on prepulse inhibition in mice deficient in the alpha subunit of G(z).

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Importance of animal models in schizophrenia research

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Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

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Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site

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The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

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Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors

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Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice

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Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia

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Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning.

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Mouse models for psychiatric disorders.

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Cortical glutamatergic markers in schizophrenia

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Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.

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The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage

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Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

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First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients

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Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

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Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats

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NMDA-induced phosphorylation and regulation of mGluR5.

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Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia

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Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus.

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The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm

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Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia

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Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex

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Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition

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The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats

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Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits.

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Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

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Schizophrenia and glutamatergic transmission

1 reference

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Focus on Childhood and Adolescent Mental Health.

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The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala.

1 reference

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7 January 2021

based on heuristic

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Tissue concentrations of clozapine and its metabolites in the rat

1 reference

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7 January 2021

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Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

1 reference

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7 January 2021

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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

1 reference

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Identifiers

10.1017/S1461145708009085

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593507

ResearchGate publication ID

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