(Q46525133)

22 December 2017

title

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit (English)

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22 December 2017

author name string

S Chandra Shekar

1

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22 December 2017

Haiyan Wu

2

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22 December 2017

Zheng Fu

3

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22 December 2017

Shu-Chin Yip

4

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22 December 2017

Nagajyothi

5

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22 December 2017

Sean M Cahill

6

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22 December 2017

Mark E Girvin

7

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22 December 2017

Jonathan M Backer

8

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22 December 2017

language of work or name

English

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publication date

2 June 2005

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22 December 2017

Journal of Biological Chemistry

published in

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22 December 2017

volume

280

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22 December 2017

page(s)

27850-27855

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22 December 2017

issue

30

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22 December 2017

cites work

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High frequency of mutations of the PIK3CA gene in human cancers

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

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Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

21 January 2018

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The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

21 January 2018

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21 January 2018

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

21 January 2018

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Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

21 January 2018

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21 January 2018

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21 January 2018

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The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch

21 January 2018

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Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M506005200

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22 December 2017

PubMed ID

15932879

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22 December 2017