Wikidata

(Q4654263)

English

mitogen-activated protein kinase kinase kinase 5

mammalian protein found in Homo sapiens

  • MAP3K5
  • apoptosis signal-regulating kinase 1
  • MAPK/ERK kinase kinase 5
  • mitogen-activated protein kinase kinase kinase 5
  • MEKK 5
  • MAP/ERK kinase kinase 5
  • MEK kinase 5
  • ASK-1
  • MAP Kinase Kinase Kinase 5
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No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
8 April 2019
stated in
Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)
GOA
curator
UniProt
UniProt protein ID
Q99683
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis.
GOA
curator
UniProt
UniProt protein ID
Q99683
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
GOA
curator
UniProt
UniProt protein ID
Q99683
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1
GOA
curator
UniProt
UniProt protein ID
Q99683
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
GOA
curator
UniProt
UniProt protein ID
Q99683
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of Daxx-mediated apoptosis by heat shock protein 27
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of the survival motor neuron protein by ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
retrieved
8 April 2019
stated in
AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99683
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE MAP3K5 203837 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D048848
subject named as
MAP Kinase Kinase Kinase 5
0 references
 
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