(Q46605092)

English

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig.

scientific article published on 16 July 2005

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

based on heuristic

inferred from title

Jens Juul Holst

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Carolyn F. Deacon

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

A Plamboeck

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

R D Carr

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

publication date

16 July 2005

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

48

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1882-1890

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16025254%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

https://scigraph.springernature.com/pub.10.1007/s00125-005-1847-7

0 references

Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS00125-005-1847-7

21 January 2018

Protective effect of omapatrilat, a vasopeptidase inhibitor, on the metabolism of bradykinin in normal and failing human hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placebo-controlled comparison of candoxatril, an orally active neutral endopeptidase inhibitor, and captopril in patients with chronic heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of UK 69 578: a novel atriopeptidase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function relations in glucagon. Properties of highly purified Des-his1-, monoiodo-, and [Des-Asn28,Thr29](homoserine lactone27)-glucagon

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasopeptidase inhibition improves insulin sensitivity and endothelial function in the JCR:LA-cp rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of kidney neutral endopeptidase after administration of the neutral endopeptidase inhibitor candoxatril: quantitation by autoradiography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dual angiotensin-converting enzyme and neutral endopeptidase 24-11 chronic inhibition by mixanpril on insulin sensitivity in lean and obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A sensitive microplate-based continuous-monitoring (kinetic) assay for serum neutral endopeptidase (EC 3.4.24.11) activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of glucagon-like peptide (GLP)-1 (7-36) amide by ectopeptidases in RINm5F cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity studies of glucagon-like peptide-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025254

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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