(Q46617662)

23 December 2017

title

Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands (English)

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23 December 2017

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Guillermo A Senisterra

1

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23 December 2017

Bum Soo Hong

2

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23 December 2017

Hee-Won Park

3

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23 December 2017

Masoud Vedadi

4

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23 December 2017

publication date

30 April 2008

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23 December 2017

Journal of Biomolecular Screening

published in

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23 December 2017

volume

13

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23 December 2017

issue

5

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23 December 2017

page(s)

337-342

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23 December 2017

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

cites work

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https://api.crossref.org/works/10.1177%2F1087057108317825

Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

High-density miniaturized thermal shift assays as a general strategy for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

An intermediate structure in the thermal unfolding of the GTPase domain of human septin 4 (SEPT4/Bradeion-beta) forms amyloid-like filaments in vitro.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu,Zn superoxide dismutases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057108317825

Metals ions and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057108317825

21 January 2018

Identifiers

DOI

10.1177/1087057108317825

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23 December 2017

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23 December 2017