(Q46620437)

23 December 2017

title

Oligo(ethylene glycol) derivatives of thioflavin T as inhibitors of protein-amyloid interactions (English)

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23 December 2017

author name string

Petra Inbar

1

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23 December 2017

Cui Q Li

2

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23 December 2017

Stacy A Takayama

3

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23 December 2017

Mahealani R Bautista

4

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23 December 2017

Jerry Yang

5

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23 December 2017

publication date

1 October 2006

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23 December 2017

published in

ChemBioChem

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23 December 2017

volume

7

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23 December 2017

issue

10

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23 December 2017

page(s)

1563-1566

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23 December 2017

Inhibiting protein-amyloid interactions with small molecules: a surface chemistry approach

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Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

21 January 2018

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Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET.

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Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease

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Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain

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Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.

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Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease

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Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)

21 January 2018

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Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism

21 January 2018

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21 January 2018

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Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB)

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21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Recognizing molecules with drug-like properties

21 January 2018

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Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

21 January 2018

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CBIC.200600119

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23 December 2017

PubMed ID

16927253

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23 December 2017