(Q46681240)

24 December 2017

title

Regulatory Forum Opinion Piece: Carcinogen Risk Assessment: The Move from Screens to Science (English)

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24 December 2017

author name string

Noel Downes

series ordinal

1

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24 December 2017

John Foster

series ordinal

2

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24 December 2017

language of work or name

English

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publication date

21 August 2015

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24 December 2017

published in

Toxicologic Pathology

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24 December 2017

volume

43

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24 December 2017

issue

8

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24 December 2017

page(s)

1064-1073

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24 December 2017

A critical review of the effectiveness of rodent pharmaceutical carcinogenesis testing in predicting for human risk

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Toxicity testing in the 21st century: bringing the vision to life

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Relevance of maximum tolerated dose to human carcinogenic risk

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The significance of mouse liver tumor formation for carcinogenic risk assessment: results and conclusions from a survey of ten years of testing by the agrochemical industry

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A critique of the use of the maximum tolerated dose in bioassays to assess cancer risks from chemicals

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Alternative models for carcinogenicity testing

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The value of historical control data-scientific advantages for pathologists, industry and agencies

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A tiered approach to systemic toxicity testing for agricultural chemical safety assessment

21 January 2018

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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

21 January 2018

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Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity

21 January 2018

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Neonatal mouse assay for tumorigenicity: alternative to the chronic rodent bioassay.

21 January 2018

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Interspecies extrapolation in carcinogenesis: prediction between rats and mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Toxicology for the twenty-first century

21 January 2018

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Carcinogenesis bioassays: study duration and biological relevance.

21 January 2018

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An examination of the association between maximum-tolerated dose and carcinogenicity in 326 long-term studies in rats and mice

21 January 2018

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21 January 2018

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21 January 2018

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History of chronic toxicity and animal carcinogenicity studies for pharmaceuticals

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Best practices for use of historical control data of proliferative rodent lesions

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Evaluation of drugs with specific organ toxicities in organ-specific cell lines

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Neonatal mouse model: review of methods and results

21 January 2018

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Spontaneous tumor incidence in rasH2 mice: review of internal data and published literature

21 January 2018

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Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans

21 January 2018

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A comprehensive survey of Ras mutations in cancer

21 January 2018

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An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: support for a proposal to modify current regulatory guidelines.

21 January 2018

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Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats

21 January 2018

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21 January 2018

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Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/0192623315598578

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24 December 2017

1 reference

24 December 2017