(Q46713087)

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Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux?

scientific article published on 8 March 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux? (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

multiple drug resistance

1 reference

based on heuristic

inferred from title

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based on heuristic

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author name string

Robert M Rutledge

1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

Michel Ghislain

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

J Michael Mullins

3

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

Cedric Pety de Thozée

4

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

John Golin

5

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

publication date

8 March 2008

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

Molecular Genetics and Genomics

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

279

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

6

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

573-583

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

https://scigraph.springernature.com/pub.10.1007/s00438-008-0334-5

0 references

A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins

1 reference

https://api.crossref.org/works/10.1007%2FS00438-008-0334-5

21 January 2018

Transcriptional control of the yeast PDR5 gene by the PDR3 gene product

1 reference

https://api.crossref.org/works/10.1007%2FS00438-008-0334-5

21 January 2018

Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases

1 reference

https://api.crossref.org/works/10.1007%2FS00438-008-0334-5

21 January 2018

Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00438-008-0334-5

21 January 2018

Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression in Escherichia coli and purification of an ATP-binding peptide from the yeast plasma membrane H(+)-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights from yeast endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular machinery of autophagy: unanswered questions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRIPLES: a database of gene function in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of Candida albicans ABC transporter Cdr1p.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18327613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00438-008-0334-5

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18327613

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