(Q46719487)

24 December 2017

title

A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene (English)

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24 December 2017

author

Justus B. Cohen

series ordinal

1

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24 December 2017

author name string

Levinson AD

series ordinal

2

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24 December 2017

language of work or name

English

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publication date

1 July 1988

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24 December 2017

published in

Nature

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24 December 2017

volume

334

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24 December 2017

page(s)

119-124

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24 December 2017

issue

6178

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24 December 2017

https://scigraph.springernature.com/pub.10.1038/334119a0

exact match

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cites work

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Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene

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Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

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Mechanism of activation of a human oncogene

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7 January 2021

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

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Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.

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Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene

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Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin

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The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

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Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

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ras gene Amplification and malignant transformation

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High-level expression of c-H-ras1 fails to fully transform rat-1 cells

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Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter.

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Transcriptional enhancer activity in the variable tandem repeat DNA sequence downstream of the human Ha-ras 1 gene

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A repetitive sequence element 3' of the human c-Ha-ras1 gene has enhancer activity

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7 January 2021

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

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Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia

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Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes

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A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

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Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumours

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7 January 2021

Expression of the affected A gamma globin gene associated with Greek nondeletion hereditary persistence of fetal hemoglobin

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7 January 2021

A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell

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Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

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A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products

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Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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7 January 2021

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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7 January 2021

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

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7 January 2021

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts

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7 January 2021

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

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Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells.

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7 January 2021

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A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient

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Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines

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Plasmid-Directed Synthesis of Hepatitis B Surface Antigen in Monkey Cells

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Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors

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Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation

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7 January 2021

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing

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Negative regulation of viral enhancers in undifferentiated embryonic stem cells

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Identifiers

DOI

10.1038/334119A0

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24 December 2017

Dimensions Publication ID

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24 December 2017