(Q46724204)

24 December 2017

title

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction (English)

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24 December 2017

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María Jesús Vázquez

1

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24 December 2017

William Leavens

2

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24 December 2017

Ronggang Liu

3

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24 December 2017

Beatriz Rodríguez

4

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24 December 2017

Martin Read

5

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24 December 2017

Stephen Richards

6

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24 December 2017

Deborah Winegar

7

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24 December 2017

Juan Manuel Domínguez

8

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24 December 2017

language of work or name

English

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publication date

25 February 2008

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24 December 2017

published in

FEBS Journal

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24 December 2017

volume

275

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24 December 2017

issue

7

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24 December 2017

page(s)

1556-1567

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24 December 2017

The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together

cites work

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THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

21 January 2018

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Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

Domain movements in human fatty acid synthase by quantized elastic deformational model

21 January 2018

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

21 January 2018

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Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?

21 January 2018

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Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

21 January 2018

1 reference

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The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons

21 January 2018

1 reference

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Hypothalamic malonyl-CoA as a mediator of feeding behavior

21 January 2018

1 reference

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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

Fatty acid metabolism as a target for obesity treatment

21 January 2018

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Synthesis and antitumor activity of an inhibitor of fatty acid synthase

21 January 2018

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Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

21 January 2018

1 reference

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C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA.

21 January 2018

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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

Inhibition of fatty acid synthase by polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

Utilization of substrate-induced quenching for screening targets promoting NADH and NADPH consumption

21 January 2018

1 reference

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Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core

21 January 2018

1 reference

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Kinetic and chemical mechanisms of the fabG-encoded Streptococcus pneumoniae beta-ketoacyl-ACP reductase

21 January 2018

1 reference

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

17 The kinetics of reversible tight-binding inhibition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06314.X

10.1111/J.1742-4658.2008.06314.X

21 January 2018

Identifiers

DOI

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24 December 2017

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24 December 2017