(Q46813375)

25 December 2017

title

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11. (English)

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25 December 2017

author

Philip M Potter

10

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25 December 2017

author name string

M Wierdl

1

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25 December 2017

L Tsurkan

2

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25 December 2017

J L Hyatt

3

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25 December 2017

C C Edwards

4

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M J Hatfield

5

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25 December 2017

C L Morton

6

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P J Houghton

7

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25 December 2017

M K Danks

8

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M R Redinbo

9

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25 December 2017

publication date

11 January 2008

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25 December 2017

published in

Cancer Gene Therapy

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25 December 2017

volume

15

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issue

3

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25 December 2017

page(s)

183-192

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25 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7701112

exact match

0 references

cites work

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

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Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children

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Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

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Development of a tumor-selective approach to treat metastatic cancer

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Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma

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7 January 2021

Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11

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7 January 2021

Secreted and tumour targeted human carboxylesterase for activation of irinotecan

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7 January 2021

Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.

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7 January 2021

Structural insights into CPT-11 activation by mammalian carboxylesterases

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7701112

7 January 2021

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

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7 January 2021

Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver

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7 January 2021

A specific chromosomal abnormality in rhabdomyosarcoma.

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Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

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7 January 2021

Analytical study of microsomes and isolated subcellular membranes from rat liver. I. Biochemical methods

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7 January 2021

Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase

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7 January 2021

Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.

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7 January 2021

Limited N-terminal sequence analysis

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7 January 2021

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model

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7 January 2021

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

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7 January 2021

Conversion of a carboxylesterase into a triacylglycerol lipase by a random mutation

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7 January 2021

Carboxylesterases--detoxifying enzymes and targets for drug therapy

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7701112

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25 December 2017

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25 December 2017