(Q46829192)

English

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

scientific article published on 30 November 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

0 references

5

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

author name string

Sridhar Natesan

1

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

Greg E Reckless

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

José N Nobrega

3

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

Paul J Fletcher

4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

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publication date

30 November 2005

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

Neuropsychopharmacology

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

31

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

9

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

1854-1863

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

Prevention by (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin of both catalepsy and the rises in rat striatal dopamine metabolism caused by haloperidol

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Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

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Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs

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The role of serotonin in antipsychotic drug action

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Differentiation of classical and novel antipsychotics using animal models.

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Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

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D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons

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Mechanism of action of aripiprazole predicts clinical efficacy and a favourable side-effect profile

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Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability

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The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor

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Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder.

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The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats

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High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study

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The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

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Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

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A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy

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Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats

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Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

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7 January 2021

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Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials

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Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors

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Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

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Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain

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Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

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Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder

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Effects of olanzapine on regional C-Fos expression in rat forebrain

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Partial dopamine agonists in the treatment of psychosis

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Antagonism at 5-HT(2A) receptors potentiates the effect of haloperidol in a conditioned avoidance response task in rats.

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Evidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat

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Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats.

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The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors

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Identifiers

10.1038/SJ.NPP.1300983

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16319908

ResearchGate publication ID

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