(Q46830870)

25 December 2017

title

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase (English)

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25 December 2017

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Galina I Lepesheva

1

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25 December 2017

Natalia G Zaitseva

2

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25 December 2017

W David Nes

3

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25 December 2017

Wenxu Zhou

4

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25 December 2017

Miharu Arase

5

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25 December 2017

Jialin Liu

6

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25 December 2017

George C Hill

7

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25 December 2017

Michael R Waterman

8

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25 December 2017

language of work or name

English

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publication date

30 November 2005

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25 December 2017

Journal of Biological Chemistry

published in

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25 December 2017

volume

281

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25 December 2017

page(s)

3577-3585

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25 December 2017

issue

6

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25 December 2017

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M510317200

The Genome of the African Trypanosome Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

The role of sterols in plant growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Second-generation azole antifungal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

The glycosome membrane of Trypanosoma cruzi epimastigotes: protein and lipid composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

CYP51--the omnipotent P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

CYP51 from Trypanosoma brucei is obtusifoliol-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Mechanism and structural requirements for transformation of substrates by the methyl transferase from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Properties and structural requirements for substrate specificity of cytochrome P-450-dependent obtusifoliol 14 α-demethylase from maize (Zea mays) seedlings

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Optimized expression and catalytic properties of a wheat obtusifoliol 14alpha-demethylase (CYP51) expressed in yeast. Complementation of erg11Delta yeast mutants by plant CYP51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Estriol bound and ligand-free structures of sterol 14alpha-demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Inhibition of cytochromes P450 by antifungal imidazole derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Emerging fungal resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis from 24,25-dihydrolanosterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Plasma non-cholesterol sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Comparative genomics of trypanosomatid parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Isolation and Reconstitution of the Heme-Thiolate Protein Obtusifoliol 14α-Demethylase fromSorghum bicolor(L.) Moench

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510317200

21 January 2018

Identifiers

DOI

10.1074/JBC.M510317200

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25 December 2017

PubMed ID

16321980

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25 December 2017