(Q46852208)

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Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I.

scientific article published in December 2007

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077689%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I (English)

1 reference

Europe PubMed Central

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29 December 2019

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Weiguo Zhu

1

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29 December 2019

Pin Xu

2

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29 December 2019

Fernando X Cuascut

3

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29 December 2019

Alison K Hall

4

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29 December 2019

Gerry S Oxford

5

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29 December 2019

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1 December 2007

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29 December 2019

Journal of Neuroscience

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29 December 2019

27

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29 December 2019

50

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29 December 2019

13770-13780

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29 December 2019

Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel role of activin in inflammation and repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin signal transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of vanilloid receptor channel activity by protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and localization of activin receptors during endochondral bone development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for activin A and follistatin involvement in the systemic inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of Capsaicin-activated Currents in the Vanilloid Receptor TRPV1 Is Decreased by the Cyclic AMP-dependent Protein Kinase Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transforming growth factor-beta superfamily of receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wounds increase activin in skin and a vasoactive neuropeptide in sensory ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of interferon regulatory factor 1 and S100C/A11 in growth inhibition by transforming growth factor beta 1 in human hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin A and follistatin in systemic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-Smad TGF-beta signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin induces tactile allodynia and increases calcitonin gene-related peptide after peripheral inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of activin in tissue repair, fibrosis, and inflammatory disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why pain gets worse: the mechanism of heat hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways in sensitization: toward a nociceptor cell biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of type II activin receptors. Binding, processing, and phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strong induction of activin expression after injury suggests an important role of activin in wound repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin exerts a neurotrophic effect on cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activin A: a novel player and inflammatory marker in inflammatory bowel disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cloned capsaicin receptor integrates multiple pain-producing stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/18077689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3822-07.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077689%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077689%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077689%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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