(Q46896462)

English

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

scientific article published on 17 January 2006

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scholarly article

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate (English)

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

1 reference

based on heuristic

inferred from title

drug interaction

0 references

1 reference

based on heuristic

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author name string

Thomas M Polasek

1

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

John O Miners

2

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

publication date

17 January 2006

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

European Journal of Clinical Pharmacology

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

62

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

203-208

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

3

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

https://scigraph.springernature.com/pub.10.1007/s00228-005-0091-x

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Pharmacokinetic drug interactions of macrolides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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A potentially hazardous interaction between erythromycin and midazolam.

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https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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Interaction between midazolam and clarithromycin: comparison with azithromycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based enzyme inactivators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

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Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic interaction between roxithromycin and midazolam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of midazolam-CYP3A inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the cytochrome P450 (CYP)-mediated metabolic properties of miocamycin: evaluation of the possibility of a metabolic intermediate complex formation with CYP, and identification of the human CYP isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of CYP3A by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16416302

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00228-005-0091-X

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16416302

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