(Q46921173)

26 December 2017

title

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy (English)

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26 December 2017

author

Kai Kaila

9

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26 December 2017

author name string

Kathrin Töllner

1

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Claudia Brandt

2

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Manuel Töpfer

3

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Gerda Brunhofer

4

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Thomas Erker

5

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Mario Gabriel

6

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Peter W Feit

7

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Jenna Lindfors

8

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Wolfgang Löscher

10

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26 December 2017

publication date

2 April 2014

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26 December 2017

published in

Annals of Neurology

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26 December 2017

volume

75

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issue

4

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26 December 2017

page(s)

550-562

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Roles of the cation-chloride cotransporters in neurological disease.

cites work

1 reference

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

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Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.

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Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

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Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus.

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Diuretics and epilepsy: will the past and present meet?

21 January 2018

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NKCC1 transporter facilitates seizures in the developing brain

21 January 2018

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Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamoylbenzoic acid derivatives

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Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy

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Giant synaptic potentials in immature rat CA3 hippocampal neurones.

21 January 2018

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The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus.

21 January 2018

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Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium?

21 January 2018

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Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats

21 January 2018

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Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy

21 January 2018

1 reference

Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue

21 January 2018

1 reference

Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures

21 January 2018

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A randomised controlled trial of bumetanide in the treatment of autism in children

21 January 2018

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Prodrug approaches for CNS delivery

21 January 2018

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Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

21 January 2018

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Cation-chloride co-transporters in neuronal communication, development and trauma

21 January 2018

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Interactions of human organic anion transporters with diuretics.

21 January 2018

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Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide

21 January 2018

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Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).

21 January 2018

1 reference

Amygdala kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex

21 January 2018

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Changes in chloride homeostasis-regulating gene expressions in the rat hippocampus following amygdala kindling

21 January 2018

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Bumetanide inhibits rapid kindling in neonatal rats

21 January 2018

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Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.

21 January 2018

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Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital.

21 January 2018

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Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.

21 January 2018

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21 January 2018

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Animal models of intractable epilepsy

21 January 2018

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Blocking seizures with the diuretic bumetanide: promises and pitfalls.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.24124

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26 December 2017

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26 December 2017