(Q46922848)

26 December 2017

title

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype (English)

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26 December 2017

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Gaedigk A

1

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26 December 2017

Simon SD

2

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26 December 2017

Pearce RE

3

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26 December 2017

Bradford LD

4

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26 December 2017

Kennedy MJ

5

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26 December 2017

Leeder JS

6

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26 December 2017

language of work or name

English

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publication date

31 October 2007

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26 December 2017

Clinical Pharmacology & Therapeutics

published in

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26 December 2017

volume

83

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26 December 2017

issue

2

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26 December 2017

page(s)

234-242

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26 December 2017

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Identification of CYP2D6 impaired functional alleles in Mexican Americans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Metabolic drug interactions with newer antipsychotics: a comparative review.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Age-dependent pharmacokinetics of lamivudine in HIV-infected children.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Investigation of terbinafine as a CYP2D6 inhibitor in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100406

7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100406

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26 December 2017

1 reference

26 December 2017