(Q46925717)

26 December 2017

title

Using Drosophila and yeast genetics to investigate a role for the Rheb GTPase in cell growth (English)

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26 December 2017

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Parthive H Patel

1

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26 December 2017

Fuyuhiko Tamanoi

series ordinal

2

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26 December 2017

language of work or name

English

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publication date

1 January 2006

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26 December 2017

published in

Methods in Enzymology

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26 December 2017

volume

407

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26 December 2017

page(s)

443-454

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26 December 2017

The Rheb family of GTP-binding proteins

cites work

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Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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Signaling by target of rapamycin proteins in cell growth control

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Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature

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Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation

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Drosophila Rheb GTPase is required for cell cycle progression and cell growth

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Ectopic gene expression in Drosophila using GAL4 system

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

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Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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Use of FLP/FRT system to study Drosophila development.

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The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

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7 January 2021

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

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7 January 2021

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

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7 January 2021

Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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7 January 2021

10.1016/S0076-6879(05)07036-9

Identifiers

DOI

1 reference

26 December 2017

PubMed ID

16757344

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26 December 2017