(Q46938110)

26 December 2017

title

The structural basis for docking in modular polyketide biosynthesis (English)

1 reference

26 December 2017

author name string

Kira J Weissman

series ordinal

1

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26 December 2017

publication date

1 March 2006

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26 December 2017

published in

ChemBioChem

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26 December 2017

volume

7

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26 December 2017

issue

3

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26 December 2017

page(s)

485-494

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26 December 2017

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

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6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

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Modular organization of genes required for complex polyketide biosynthesis

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The structure of docking domains in modular polyketide synthases

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Role of linkers in communication between protein modules

21 January 2018

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Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

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Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

21 January 2018

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

21 January 2018

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Genetic fusion of subunits of a dimeric protein substantially enhances its stability and rate of folding

21 January 2018

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High-resolution structure of the HNF-1alpha dimerization domain

21 January 2018

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IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea

21 January 2018

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

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Site-specific integration of bacteriophage VWB genome into Streptomyces venezuelae and construction of a VWB-based integrative vector.

21 January 2018

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

21 January 2018

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Intergeneric conjugation in Streptomyces peucetius and Streptomyces sp. strain C5: chromosomal integration and expression of recombinant plasmids carrying the chiC gene

21 January 2018

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Genetic manipulation of antibiotic-producing Streptomyces

21 January 2018

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Integration site for Streptomyces phage phiBT1 and development of site-specific integrating vectors

21 January 2018

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Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases

21 January 2018

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Catalytically active tetramodular 6-deoxyerythonolide B synthase fusion proteins.

21 January 2018

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Intergeneric conjugation between Escherichia coli and Streptomyces species

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21 January 2018

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Identifiers

DOI

10.1002/CBIC.200500435

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26 December 2017

PubMed ID

16470766

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26 December 2017