(Q46943601)

English

Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice

scientific article published on 14 February 2006

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scholarly article

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice (English)

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

atherosclerosis

1 reference

based on heuristic

inferred from title

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author name string

Rai Ajit K Srivastava

1

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Ravi Jahagirdar

2

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Salman Azhar

3

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Somesh Sharma

4

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Charles L Bisgaier

5

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

publication date

14 February 2006

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

Molecular and Cellular Biochemistry

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

285

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

1-2

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

35-50

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

https://scigraph.springernature.com/pub.10.1007/s11010-005-9053-y

0 references

A review of rosiglitazone in type 2 diabetes mellitus

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https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

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Diabetes, hypertension, and cardiovascular disease: an update

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https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats

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https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Obesity, insulin resistance, and cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Dietary fatty acids and dietary cholesterol differ in their effect on the in vivo regulation of apolipoprotein A-I and A-II gene expression in inbred strains of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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Fenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic syndrome: a clinical and molecular perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dialyzable leukocyte extract differentially regulates the production of TNFalpha, IL-6, and IL-8 in bacterial component-activated leukocytes and endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of insulin resistance in human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

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The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus: a cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of muscle in triglyceride metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of RNA by Northern blotting using riboprobes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed ham

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A natural product that lowers cholesterol as an antagonist ligand for FXR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen Up-regulates Apolipoprotein E (ApoE) Gene Expression by Increasing ApoE mRNA in the Translating Pool via the Estrogen Receptor α-Mediated Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein abnormalities and their consequences for patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the apolipoprotein B in heterozygous hypobetalipoproteinemic knock-out mice expressing truncated apoB, B81. Low production and enhanced clearance of apoB cause low levels of apoB

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The triglyceride-high-density lipoprotein axis: an important target of therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of PPAR-alpha ligand-mediated physiological changes using gene expression profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triglycerides and coronary heart disease: implications of recent clinical trials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16477380

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-005-9053-Y

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16477380

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