(Q46959635)

26 December 2017

review article

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title

Murine mentors: transgenic and knockout models of surgical disease (English)

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26 December 2017

author name string

J M Arbeit

series ordinal

1

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26 December 2017

R Hirose

series ordinal

2

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26 December 2017

language of work or name

English

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publication date

1 January 1999

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26 December 2017

published in

Annals of Surgery

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26 December 2017

volume

229

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26 December 2017

issue

1

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26 December 2017

page(s)

21-40

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26 December 2017

Normal genetically mosaic mice produced from malignant teratocarcinoma cells

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12 December 2020

The biology of mammary transgenes: five rules

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12 December 2020

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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12 December 2020

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

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12 December 2020

Effects of an Rb mutation in the mouse

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12 December 2020

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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12 December 2020

Atherogenesis in transgenic mice expressing human apolipoprotein(a)

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12 December 2020

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

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12 December 2020

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia

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12 December 2020

Identification and characterization of the familial adenomatous polyposis coli gene

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12 December 2020

Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice

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12 December 2020

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

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12 December 2020

CD8 is needed for development of cytotoxic T cells but not helper T cells

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12 December 2020

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

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12 December 2020

Wound healing in the transforming growth factor-beta-deficient mouse.

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12 December 2020

Liver cancer in transgenic mice carrying the human immunodeficiency virus tat gene

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12 December 2020

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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12 December 2020

Malignant melanoma in transgenic mice.

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12 December 2020

Analysis of hepadnavirus gene expression, biology, and pathogenesis in the transgenic mouse

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12 December 2020

Mice lacking MHC class II molecules

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12 December 2020

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

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12 December 2020

Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene

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12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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12 December 2020

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

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12 December 2020

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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12 December 2020

Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice

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12 December 2020

Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice

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12 December 2020

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

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12 December 2020

Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta

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12 December 2020

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

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12 December 2020

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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12 December 2020

Bovine papillomavirus genome elicits skin tumours in transgenic mice

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12 December 2020

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

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12 December 2020

Dissecting multistep tumorigenesis in transgenic mice

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12 December 2020

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

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12 December 2020

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12 December 2020

Germ-line transformation of mice

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12 December 2020

Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.

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12 December 2020

Association of Megacolon with Two Recessive Spotting Genes in the Mouse

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12 December 2020

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

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12 December 2020

Establishment in culture of pluripotential cells from mouse embryos

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12 December 2020

Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.

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12 December 2020

Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation

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12 December 2020

Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin

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12 December 2020

Targeted disruption of the neuronal nitric oxide synthase gene.

1 reference

12 December 2020

Embryonic mesodermal defects in alpha 5 integrin-deficient mice

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12 December 2020

Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. A potential approach for preventing xenograft rejection.

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12 December 2020

Physiological consequences of over- or under-expression of fibrinolytic system components in transgenic mice

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12 December 2020

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

1 reference

12 December 2020

Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology

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12 December 2020

Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury

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12 December 2020

Heart and lung disease in engineered mice

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12 December 2020

Tolerance and xenograft survival

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12 December 2020

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1

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12 December 2020

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

1 reference

12 December 2020

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

1 reference

12 December 2020

Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.

1 reference

12 December 2020

Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion

1 reference

12 December 2020

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

1 reference

12 December 2020

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

1 reference

12 December 2020

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

1 reference

12 December 2020

Survival of MHC-deficient mouse heterotopic cardiac allografts

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12 December 2020

Cardiac malformation in neonatal mice lacking connexin43.

1 reference

12 December 2020

Lymphocyte ontogeny and activation in gene targeted mutant mice

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12 December 2020

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

12 December 2020

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

12 December 2020

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1 reference

12 December 2020

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

1 reference

12 December 2020

The function of KGF in morphogenesis of epithelium and reepithelialization of wounds

1 reference

12 December 2020

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1 reference

12 December 2020

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1 reference

12 December 2020

PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse.

1 reference

12 December 2020

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice

1 reference

12 December 2020

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

1 reference

12 December 2020

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1 reference

12 December 2020

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1 reference

12 December 2020

Mutations of the RET proto-oncogene in Hirschsprung's disease

1 reference

12 December 2020

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1 reference

12 December 2020

Molecular dissection of multi-stage tumorigenesis in transgenic mice

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12 December 2020

Mammary tumorigenesis and metastasis in transgenic mice.

1 reference

12 December 2020

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1 reference

12 December 2020

Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).

1 reference

12 December 2020

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

1 reference

12 December 2020

Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.

1 reference

12 December 2020

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1 reference

12 December 2020

Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

1 reference

12 December 2020

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

1 reference

12 December 2020

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

1 reference

12 December 2020

Major histocompatibility complex class I deficiency prolongs islet allograft survival.

1 reference

12 December 2020

Transgenic mouse models of lipoprotein metabolism and atherosclerosis

1 reference

12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

12 December 2020

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

12 December 2020

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

12 December 2020

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

1 reference

12 December 2020

Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis.

1 reference

12 December 2020

Keratinocyte growth factor is required for hair development but not for wound healing

1 reference

12 December 2020

Mutation and cancer: a personal odyssey

1 reference

12 December 2020

Transgenic models and cancer treatment

1 reference

12 December 2020

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

12 December 2020

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

1 reference

12 December 2020

Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium

1 reference

12 December 2020

Impaired wound healing in mice with a disrupted plasminogen gene

1 reference

12 December 2020

Gi2 alpha protein deficiency: a model of inflammatory bowel disease

1 reference

12 December 2020

Genes and physiology: molecular physiology in genetically engineered animals

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12 December 2020

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1 reference

12 December 2020

Use of MHC class I or II "knock out" mice to delineate the role of these molecules in acceptance/rejection of xenografts.

1 reference

12 December 2020

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam

1 reference

12 December 2020

Role of the thrombin receptor in development and evidence for a second receptor.

1 reference

12 December 2020

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1 reference

12 December 2020

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1 reference

12 December 2020

Defects in enteric innervation and kidney development in mice lacking GDNF

1 reference

12 December 2020

Renal and neuronal abnormalities in mice lacking GDNF

1 reference

12 December 2020

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

1 reference

12 December 2020

Transforming growth factor-beta1-deficient mice: identification of isoform-specific activities in vivo.

1 reference

12 December 2020

Skin wounds and severed nerves heal normally in mice lacking tenascin-C

1 reference

12 December 2020

Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase

1 reference

12 December 2020

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase

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12 December 2020

Conditional gene targeting

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12 December 2020

Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl

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12 December 2020

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth

1 reference

12 December 2020

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice

1 reference

12 December 2020

Antigen processing and presentation by the class I major histocompatibility complex

1 reference

12 December 2020

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment

1 reference

12 December 2020

Transgenic models of epidermal neoplasia and multistage carcinogenesis.

1 reference

12 December 2020

Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review

1 reference

12 December 2020

Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development

1 reference

12 December 2020

Ligand-activated site-specific recombination in mice

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12 December 2020

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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12 December 2020

Lessons from hereditary colorectal cancer

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12 December 2020

Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice

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12 December 2020

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

1 reference

12 December 2020

P53 gene alterations in human tumors: perspectives for cancer control.

1 reference

12 December 2020

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

1 reference

12 December 2020

CD4+ but not CD8+ cells are essential for allorejection

1 reference

12 December 2020

Upregulation of fibroblast growth factors and their receptors during multi-stage epidermal carcinogenesis in K14-HPV16 transgenic mice

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12 December 2020

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12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

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12 December 2020

Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.

1 reference

12 December 2020

Patterns of mutation in cancer cells

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12 December 2020

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

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12 December 2020

Acute rejection of vascularized heart allografts in the absence of IFNgamma

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12 December 2020

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

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12 December 2020

Antigen presentation by MHC class II molecules

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12 December 2020

Studies of transplantation immunology with major histocompatibility complex knockout mice

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12 December 2020

Ligand-inducible and liver-specific target gene expression in transgenic mice

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12 December 2020

Cre-mediated somatic site-specific recombination in mice

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12 December 2020

DNA mismatch repair deficient mice in cancer research

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12 December 2020

Manipulation of the mouse germline in the study of Min-induced neoplasia

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12 December 2020

Mutations predisposing to hereditary nonpolyposis colorectal cancer

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12 December 2020

Clinical xenotransplantation of solid organs

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12 December 2020

Transplantation of normal and DAF-transgenic fetal pig pancreas into cynomolgus monkeys

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12 December 2020

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

12 December 2020

CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts

1 reference

12 December 2020

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

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12 December 2020

New directions in breast cancer research

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12 December 2020

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

1 reference

12 December 2020

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

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12 December 2020

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

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12 December 2020

10.1097/00000658-199901000-00004

Identifiers

DOI

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26 December 2017

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26 December 2017