(Q46986556)

English

A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct

scientific article published on 10 March 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

author name string

Palaniappa Arjunan

1

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Martin Sax

2

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Andrew Brunskill

3

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Krishnamoorthy Chandrasekhar

4

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Natalia Nemeria

5

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Sheng Zhang

6

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Frank Jordan

7

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

William Furey

8

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

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publication date

10 March 2006

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

281

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

22

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

15296-15303

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography

1 reference

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21 January 2018

Dual Catalytic Apparatus of the Thiamin Diphosphate Coenzyme: Acid−Base via the 1‘,4‘-Iminopyrimidine Tautomer along with Its Electrophilic Role

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and tra

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Bioassay for carcinogenicity of rotenone in female Wistar rats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Conformation of Polypeptides and Proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Stereochemistry of intermediates in thiamine catalysis. 2. Crystal structure of DL-2-(alpha-hydroxybenzyl)thiamine chloride hydrochloride trihydrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Recognition of the lipoyl domain is the ultimate determinant of substrate channelling in the pyruvate dehydrogenase multienzyme complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

A molecular switch and proton wire synchronize the active sites in thiamine enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600656200

21 January 2018

Identifiers

10.1074/JBC.M600656200

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16531404

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