(Q47073900)

English

A zebrafish model of CLN2 disease is deficient in tripeptidyl peptidase 1 and displays progressive neurodegeneration accompanied by a reduction in proliferation

scientific article published on 15 April 2013

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scholarly article

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

A zebrafish model of CLN2 disease is deficient in tripeptidyl peptidase 1 and displays progressive neurodegeneration accompanied by a reduction in proliferation (English)

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Tripeptidyl peptidase I

1 reference

GOA release 2020-03-11

neurodegeneration

1 reference

based on heuristic

inferred from title

Stephen W Wilson

4

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Jonathan D. Cooper

5

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

author name string

Fahad Mahmood

1

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Sonia Fu

2

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Jennifer Cooke

3

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Claire Russell

6

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

language of work or name

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publication date

15 April 2013

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

136

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Pt 5

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Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

1488-1507

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

Loss of PINK1 function affects development and results in neurodegeneration in zebrafish

1 reference

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MRI of neuronal ceroid lipofuscinosis. II. Postmortem MRI and histopathological study of the brain in 16 cases of neuronal ceroid lipofuscinosis of juvenile or late infantile type.

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A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis

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21 January 2018

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

1 reference

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21 January 2018

A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.

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Biosynthesis, glycosylation, and enzymatic processing in vivo of human tripeptidyl-peptidase I.

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Zebrafish as a pharmacological tool: the how, why and when

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Lysosomal storage of subunit c of mitochondrial ATP synthase in Batten's disease (ceroid-lipofuscinosis)

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Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis.

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

Patterning the brain of the zebrafish embryo

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21 January 2018

Stages of embryonic development of the zebrafish

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21 January 2018

Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

Pathological study on sibling autopsy cases of the late infantile form of neuronal ceroid lipofuscinosis.

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

The first three Russian cases of classical, late-infantile, neuronal ceroid lipofuscinosis

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT043

21 January 2018

Proteomics of early zebrafish embryos

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21 January 2018

Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening

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21 January 2018

In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation

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Selectivity and types of cell death in the neuronal ceroid lipofuscinoses

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A novel functional role of iduronate-2-sulfatase in zebrafish early development.

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Anatomy of neurogenesis in the early zebrafish brain

1 reference

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Neuronal ceroid-lipofuscinosis: a clinical and morphological study of 19 patients.

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Effective targeted gene 'knockdown' in zebrafish

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Neuroradiological findings in classical late infantile neuronal ceroid-lipofuscinosis.

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Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis

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A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration

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Identifiers

10.1093/BRAIN/AWT043

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

1 reference

Europe PubMed Central

5 January 2018

http://europepmc.org/abstract/MED/23587805

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