(Q47099176)

English

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity.

scientific article published on 25 November 2016

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

stereoselectivity

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

4

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28 March 2020

1

1 reference

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28 March 2020

author name string

Gopeekrishnan Sreenilayam

2

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28 March 2020

Vikas Tyagi

3

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28 March 2020

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publication date

25 November 2016

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28 March 2020

Angewandte Chemie International Edition

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28 March 2020

55

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28 March 2020

52

1 reference

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28 March 2020

16110-16114

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

1 reference

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23 May 2018

Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin

1 reference

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23 May 2018

Myoglobin-Catalyzed Olefination of Aldehydes

1 reference

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23 May 2018

Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation

1 reference

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23 May 2018

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation.

1 reference

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23 May 2018

Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

1 reference

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23 May 2018

Guidelines for development and implementation of biocatalytic P450 processes

1 reference

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23 May 2018

Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

1 reference

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23 May 2018

P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions

1 reference

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Residues Controlling Facial Selectivity in an Alkene Reductase and Semirational Alterations to Create Stereocomplementary Variants

1 reference

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23 May 2018

Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran

1 reference

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23 May 2018

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Enantiocomplementary enzymes: classification, molecular basis for their enantiopreference, and prospects for mirror-image biotransformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Stereoselective cyclopropanation reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

23 May 2018

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

1 reference

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15 August 2018

Synthesis of chiral 2-alkanols from n-alkanes by a P. putida whole-cell biocatalyst.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Diastereoselective and enantioselective cyclopropanation of alkenes catalyzed by cobalt porphyrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Asymmetric inter- and intramolecular cyclopropanation of alkenes catalyzed by chiral ruthenium porphyrins. Synthesis and crystal structure of a chiral metalloporphyrin carbene complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

15 August 2018

Recent developments in asymmetric cyclopropanation

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

21 January 2018

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

21 January 2018

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

21 January 2018

Arylcycloalkylamines. I. 2-Phenylcyclopropylamine

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

21 January 2018

Whole-cell double oxidation of n-heptane

1 reference

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3 November 2018

Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5755974

3 November 2018

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

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Asymmetric Cyclopropanation of Olefins Catalyzed by Chiral Cobalt(II)-Binaphthyl Porphyrins

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201608680

21 January 2018

Designing ‘Totem’C2-Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations

1 reference

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21 January 2018

Absolute configuration of (+)- and (-)-trans-2-phenylcyclopropylamine hydrochloride

1 reference

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inferred from PubMed ID database lookup

Recent Advances in Asymmetric Catalytic Metal Carbene Transformations

1 reference

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inferred from PubMed ID database lookup

Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents

1 reference

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From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27885768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bis(oxazolines) as chiral ligands in metal-catalyzed asymmetric reactions. Catalytic, asymmetric cyclopropanation of olefins

1 reference

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1 reference

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Identifiers

10.1002/ANIE.201608680

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27885768%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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