(Q47161820)

English

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

scientific article published on 12 October 2017

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals (English)

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

author name string

Junjie Xu

1

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Longbo Zheng

2

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Jiang Chen

3

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Yin Sun

4

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Hui Lin

5

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Ren-An Jin

6

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Minyue Tang

7

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Xiao Liang

8

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Xiujun Cai

9

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

publication date

12 October 2017

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Cell Death and Disease

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

8

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

10

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

e3095

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

copyright license

Creative Commons Attribution 4.0 International

1 October 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1038/cddis.2017.411

0 references

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.

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23 May 2018

The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Sorafenib with ASC-J9® synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Targeting Androgen Receptor (AR)→IL12A Signal Enhances Efficacy of Sorafenib plus NK Cells Immunotherapy to Better Suppress HCC Progression

1 reference

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23 May 2018

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

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23 May 2018

MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

1 reference

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23 May 2018

Hepatic stellate cell coculture enables sorafenib resistance in Huh7 cells through HGF/c-Met/Akt and Jak2/Stat3 pathways

1 reference

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23 May 2018

SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells

1 reference

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23 May 2018

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

1 reference

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23 May 2018

The impact of hypoxia in hepatocellular carcinoma metastasis.

1 reference

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23 May 2018

Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis

1 reference

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23 May 2018

Cancer statistics, 2012

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23 May 2018

Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Targeted therapies for hepatocellular carcinoma.

1 reference

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23 May 2018

Global cancer statistics

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23 May 2018

Sorafenib: where do we go from here?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Systematic review: outcome of compensated cirrhosis due to chronic hepatitis C infection.

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23 May 2018

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

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23 May 2018

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

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23 May 2018

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Sorafenib in advanced hepatocellular carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680567

23 May 2018

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models

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23 May 2018

The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

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23 May 2018

Hepatocellular carcinoma

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23 May 2018

Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells

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23 May 2018

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

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23 May 2018

Phase II study of flutamide in the treatment of hepatocellular carcinoma

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23 May 2018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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23 May 2018

Effect of antiandrogen treatment on chemical hepatocarcinogenesis in rats

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23 May 2018

Liver cancer: sorafenib resistance uncovered by novel RNAi screen.

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15 August 2018

Efficiency and side effects of sorafenib therapy for advanced hepatocellular carcinoma: a retrospective study by the anatolian society of medical oncology

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15 August 2018

Gender disparity of hepatocellular carcinoma: the roles of sex hormones.

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15 August 2018

Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.

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15 August 2018

Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib.

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15 August 2018

Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen

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15 August 2018

Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

1 reference

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7 January 2021

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10.1038/CDDIS.2017.411

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 January 2018

http://europepmc.org/abstract/PMC/5680567

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