(Q47266083)

12 January 2018

title

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage (English)

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12 January 2018

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J C Fleishaker

1

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12 January 2018

J Fiedler-Kelly

series ordinal

2

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12 January 2018

T H Grasela

series ordinal

3

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12 January 2018

publication date

1 April 1999

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12 January 2018

published in

Pharmaceutical Research

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12 January 2018

volume

16

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12 January 2018

issue

4

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12 January 2018

page(s)

575-583

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12 January 2018

Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand

cites work

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12 December 2020

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.

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12 December 2020

Multiple-dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers

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12 December 2020

A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in North America

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12 December 2020

The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers

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12 December 2020

Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults

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12 December 2020

Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: I. Single-dose administration

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12 December 2020

Lack of pharmacokinetic interaction between cimetidine and tirilazad mesylate

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12 December 2020

Induction of tirilazad clearance by phenytoin

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12 December 2020

Phenytoin causes a rapid increase in 6 beta-hydroxycortisol urinary excretion in humans--a putative measure of CYP3A induction

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12 December 2020

Gender does not affect the degree of induction of tirilazad clearance by phenobarbital.

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12 December 2020

Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: II. Multiple-dose administration

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12 December 2020

Lack of a pharmacokinetic/pharmacodynamic interaction between nimodipine and tirilazad mesylate in healthy volunteers

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12 December 2020

Effect of age and gender on tirilazad pharmacokinetics in humans

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12 December 2020

Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability

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12 December 2020

Pharmacokinetics of tirilazad in healthy male subjects at doses above 6 mg/kg/day

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12 December 2020

Comparison of the pharmacokinetics of tirilazad mesylate in healthy volunteers and stable subjects with mild liver cirrhosis.

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12 December 2020

Effect of Gender and Menopausal Status on the Pharmacokinetics of Tirilazad Mesylate in Healthy Subjects

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12 December 2020

Identifiers

DOI

10.1023/A:1018835516040

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12 January 2018

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12 January 2018