(Q47290473)

13 January 2018

title

Size and sulfation are critical for the effect of heparin on APP processing and Aβ production (English)

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13 January 2018

author

Glenn A Jacobson

5

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13 January 2018

author name string

Hao Cui

1

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13 January 2018

Amos C Hung

2

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13 January 2018

Craig Freeman

3

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13 January 2018

Christian Narkowicz

4

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13 January 2018

David H Small

6

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13 January 2018

language of work or name

English

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publication date

21 September 2012

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13 January 2018

Journal of Neurochemistry

published in

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13 January 2018

volume

123

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13 January 2018

issue

3

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13 January 2018

page(s)

447-457

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13 January 2018

Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Studies on the structural variations of pentosan polysulfate sodium (NaPPS) from different sources by capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Global prevalence of dementia: a Delphi consensus study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Fucoidan: structure and bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

The blood-brain barrier accessibility of a heparin-derived oligosaccharides C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Synthesis of thrombin-inhibiting heparin mimetics without side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Alzheimer's disease therapeutics: new approaches to an ageing problem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2012.07929.X

10.1111/J.1471-4159.2012.07929.X

21 January 2018

Identifiers

DOI

1 reference

13 January 2018

release_2pbuxwm4g5aglagszqu5sibb2y

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2pbuxwm4g5aglagszqu5sibb2y

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

13 January 2018