(Q47309908)

13 January 2018

title

High incidence of thymic epithelial tumors in E2F2 transgenic mice (English)

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13 January 2018

author

René Bernards

5

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13 January 2018

author name string

Blanca Scheijen

1

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13 January 2018

Marieke Bronk

2

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13 January 2018

Tiffany van der Meer

3

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Daphne De Jong

4

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language of work or name

English

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publication date

18 December 2003

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13 January 2018

Journal of Biological Chemistry

published in

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volume

279

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issue

11

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13 January 2018

page(s)

10476-10483

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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

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E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

21 January 2018

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Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.

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Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.

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The E2F1-3 transcription factors are essential for cellular proliferation.

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Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

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E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells

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Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice

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Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

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Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia

21 January 2018

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Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia

21 January 2018

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The Rb/E2F pathway: expanding roles and emerging paradigms

21 January 2018

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Distinct roles for E2F proteins in cell growth control and apoptosis

21 January 2018

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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

21 January 2018

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Stem cells in epithelial tissues

21 January 2018

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Expression patterns of the E2F family of transcription factors during mouse nervous system development

21 January 2018

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pRb and p107 regulate E2F activity during lens fiber cell differentiation

21 January 2018

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21 January 2018

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Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes

21 January 2018

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c-fos expression interferes with thymus development in transgenic mice.

21 January 2018

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Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation

21 January 2018

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Thymic epithelial tumour progression in an SV40T transgenic mouse model

21 January 2018

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Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity

21 January 2018

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Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

21 January 2018

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Complex lymphoid and epithelial thymic tumours in Thyl-myc transgenic mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M313682200

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13 January 2018

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13 January 2018