(Q47388835)

15 January 2018

title

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner (English)

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15 January 2018

author name string

Yochai Birnbaum

1

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15 January 2018

Bo Long

2

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15 January 2018

Jinqiao Qian

3

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15 January 2018

Jose R Perez-Polo

4

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15 January 2018

Yumei Ye

5

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15 January 2018

publication date

1 March 2011

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15 January 2018

Basic Research in Cardiology

published in

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15 January 2018

volume

106

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15 January 2018

issue

3

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15 January 2018

page(s)

431-446

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15 January 2018

https://scigraph.springernature.com/pub.10.1007/s00395-011-0162-3

exact match

0 references

cites work

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Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury

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Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.

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Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning

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Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice.

21 January 2018

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Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression

21 January 2018

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PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway

21 January 2018

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21 January 2018

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Kinases and phosphatases in ischaemic preconditioning: a re-evaluation

21 January 2018

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21 January 2018

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21 January 2018

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Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth fac

21 January 2018

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Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial

21 January 2018

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

21 January 2018

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21 January 2018

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21 January 2018

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The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Thiazolidinediones and risk for atherosclerosis: pleiotropic effects of PPar gamma agonism

21 January 2018

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Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion.

21 January 2018

1 reference

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15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma

21 January 2018

1 reference

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Ischemic postconditioning in pigs: no causal role for RISK activation.

21 January 2018

1 reference

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Effects of PPARγ on hypertension, atherosclerosis, and chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

PPAR-gamma activation fails to provide myocardial protection in ischemia and reperfusion in pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-011-0162-3

10.1007/S00395-011-0162-3

21 January 2018

Identifiers

DOI

1 reference

15 January 2018

PubMed ID

21360043

1 reference

15 January 2018