(Q47581900)

4 February 2018

title

Dynamics of Aβ42 reduction in plasma, CSF and brain of rats treated with the γ-secretase modulator, GSM-10h (English)

1 reference

4 February 2018

author name string

Julie Hawkins

1

1 reference

4 February 2018

David C Harrison

2

1 reference

4 February 2018

Sharlin Ahmed

3

1 reference

4 February 2018

Robert P Davis

4

1 reference

4 February 2018

Trevor Chapman

5

1 reference

4 February 2018

Ian Marshall

6

1 reference

4 February 2018

Beverley Smith

7

1 reference

4 February 2018

Tania L Mead

8

1 reference

4 February 2018

Andrew Medhurst

9

1 reference

4 February 2018

Ged M P Giblin

10

1 reference

4 February 2018

Adrian Hall

11

1 reference

4 February 2018

Maria I Gonzalez

12

1 reference

4 February 2018

Jill Richardson

13

1 reference

4 February 2018

Ishrut Hussain

14

1 reference

4 February 2018

publication date

10 March 2011

1 reference

4 February 2018

Neurodegenerative Diseases

published in

1 reference

4 February 2018

volume

8

1 reference

4 February 2018

issue

6

1 reference

4 February 2018

page(s)

455-464

1 reference

4 February 2018

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

cites work

1 reference

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

1 reference

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

21 January 2018

1 reference

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

1 reference

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

Memapsin 2 (beta-secretase) inhibitors: drug development

21 January 2018

1 reference

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

1 reference

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

Gamma-secretase modulation and its promise for Alzheimer's disease: a rationale for drug discovery.

21 January 2018

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

21 January 2018

1 reference

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

21 January 2018

1 reference

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

21 January 2018

1 reference

Piperidine-derived gamma-secretase modulators

21 January 2018

1 reference

TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to γ-Secretase Modulation and Amyloid-β<sub>42</sub> Lowering by GSM-10h

21 January 2018

1 reference

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro

21 January 2018

1 reference

In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.

21 January 2018

1 reference

The bHLH gene Hes1 regulates differentiation of multiple cell types

21 January 2018

1 reference

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

21 January 2018

1 reference

Therapeutic potential of gamma-secretase inhibitors and modulators

21 January 2018

1 reference

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

21 January 2018

1 reference

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

1 reference

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

21 January 2018

1 reference

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000324511

1 reference

4 February 2018

1 reference

4 February 2018