(Q47734660)

5 February 2018

title

Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging (English)

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5 February 2018

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Jeong W Pak

1

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5 February 2018

Allen Herbst

2

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5 February 2018

Entela Bua

3

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5 February 2018

Nolan Gokey

4

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5 February 2018

Debbie McKenzie

5

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5 February 2018

Judd M Aiken

6

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5 February 2018

publication date

1 February 2003

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5 February 2018

published in

Aging Cell

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5 February 2018

volume

2

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5 February 2018

issue

1

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5 February 2018

page(s)

1-7

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5 February 2018

Relationship of genotype to phenotype in fibroblast-derived transmitochondrial cell lines carrying the 3243 mutation associated with the MELAS encephalomyopathy: shift towards mutant genotype and role of mtDNA copy number

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

An mtDNA mutation in the initiation codon of the cytochrome C oxidase subunit II gene results in lower levels of the protein and a mitochondrial encephalomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Replication of animal mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Mitochondrial DNA mutations in human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

ANT1, Twinkle, POLG, and TP: new genes open our eyes to ophthalmoplegia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Repair of alkylation and oxidative damage in mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Mammalian mitochondria possess homologous DNA recombination activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00034.X

10.1046/J.1474-9728.2003.00034.X

21 January 2018

Identifiers

DOI

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5 February 2018

1 reference

5 February 2018