(Q47747820)

5 February 2018

title

Advancing the drug discovery and development process (English)

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5 February 2018

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K C Nicolaou

1

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5 February 2018

language of work or name

English

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publication date

13 July 2014

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5 February 2018

Angewandte Chemie International Edition

published in

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volume

53

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5 February 2018

issue

35

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5 February 2018

page(s)

9128-9140

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5 February 2018

The emergence of the structure of the molecule and the art of its synthesis

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Lead- and drug-like compounds: the rule-of-five revolution

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Physiochemical drug properties associated with in vivo toxicological outcomes

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The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

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Escape from flatland: increasing saturation as an approach to improving clinical success.

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The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

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What do medicinal chemists actually make? A 50-year retrospective

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Phase III and submission failures: 2007–2010

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

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The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities

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Tough times for medicinal chemists: are we to blame?

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Translational paradigms in pharmacology and drug discovery

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Ligand efficiency: a useful metric for lead selection

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Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

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The influence of drug-like concepts on decision-making in medicinal chemistry

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Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties

21 January 2018

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Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysis

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Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

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Quantifying the chemical beauty of drugs.

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Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

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Shifting from the single to the multitarget paradigm in drug discovery

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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

21 January 2018

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Drug discovery: follow your lead

21 January 2018

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Mechanistic systems modeling to guide drug discovery and development

21 January 2018

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Oxetanes as versatile elements in drug discovery and synthesis

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Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors

21 January 2018

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Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery

21 January 2018

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

21 January 2018

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

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Biology-oriented synthesis

21 January 2018

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Organic synthesis toward small-molecule probes and drugs

21 January 2018

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Antibody-drug conjugates: an emerging concept in cancer therapy

21 January 2018

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Fluorine in pharmaceuticals: looking beyond intuition

21 January 2018

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Halogen bonding based recognition processes: a world parallel to hydrogen bonding

21 January 2018

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Halogen atoms in the modern medicinal chemistry: hints for the drug design.

21 January 2018

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Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

21 January 2018

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Patient-derived xenografts, the cancer stem cell paradigm, and cancer pathobiology in the 21st century

21 January 2018

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21 January 2018

Congenital neutropenia

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Bringing together the academic drug discovery community

21 January 2018

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The importance of chemistry for the future of the pharma industry.

21 January 2018

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The future of medicinal chemistry.

21 January 2018

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21 January 2018

2013 FDA drug approvals

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A medicinal chemistry perspective on melting point: matched molecular pair analysis of the effects of simple descriptors on the melting point of drug-like compounds

21 January 2018

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Editorial: Drug Discovery …︁ The Third in the Band!

21 January 2018

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Drug Discovery: A Modern Decathlon

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201404761

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5 February 2018

1 reference

5 February 2018