(Q47758773)

5 February 2018

review article

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title

The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins (English)

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5 February 2018

author name string

Bernkop-Schnürch A

series ordinal

1

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5 February 2018

language of work or name

English

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publication date

1 March 1998

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5 February 2018

Journal of Controlled Release

published in

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5 February 2018

volume

52

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5 February 2018

issue

1-2

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5 February 2018

page(s)

1-16

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5 February 2018

Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs

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7 January 2021

Oral absorption of peptides: the effect of absorption site and enzyme inhibition on the systemic availability of metkephamid

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7 January 2021

Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats

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7 January 2021

A new, highly sensitive and specific assay for chymotrypsin

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7 January 2021

Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N

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https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Human liver aminopeptidase. Role of metal ions in mechanism of action

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https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Effect of pH, Dietary Proteins and Trypsin Inhibitors on the Hydrolytic Rate of Human Granulocyte Colony-Stimulating Factor (G-CSF) by Rat Digestive Enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Stability of acyl derivatives of insulin in the small intestine: relative importance of insulin association characteristics in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: implications in peptide delivery from nonoral routes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Metabolism and transport of the pentapeptide metkephamid by brush-border membrane vesicles of rat intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Enzymatic cleavage of thymopoietin oligopeptides by pancreatic and intestinal brush-border enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Vasopressin: a model for the study of effects of additives on the oral and rectal administration of peptide drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Liposomal immunisation against snake venoms.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Does bacitracin have an absorption-enhancing effect in the intestine?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Effect of synthetic protease inhibitor camostate on pancreatic exocrine function in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Further studies of the effects of raw soya flour on the rat pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

The effect of trypsin inhibitor on the pancreas and small intestine of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Bioavailability of 1-deamino-8-D-arginine vasopressin with an enzyme inhibitor (aprotinin) from the small intestine in healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Expression and excretion of human pancreatic secretory trypsin inhibitor in lipoprotein-deletion mutant of Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, , and C1 esterase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Flavonoid inhibitors of trypsin and leucine aminopeptidase: a proposed mathematical model for IC50 estimation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Peptide glyoxals: a novel class of inhibitor for serine and cysteine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Purification and properties of human intestine alanine aminopeptidase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Susceptibility of ebiratide to proteolysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Intestinal uptake of dipeptides and beta-lactam antibiotics. I. The intestinal uptake system for dipeptides and beta-lactam antibiotics is not part of a brush border membrane peptidase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

A phosphinic acid dipeptide analogue to stabilize peptide drugs during their intranasal absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

The use of alpha-aminoboronic acid derivatives to stabilize peptide drugs during their intranasal absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Topology of microvillar membrance hydrolases of kidney and intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase M

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Investigation into the intestinal metabolism of [D-Ala1] peptide T amide: implication for oral drug delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Role of angiotensin converting enzyme and other peptidases in in vivo metabolism of kinins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

The adjuvant effect of bacitracin on nasal absorption of gonadorelin and buserelin in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effects

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

New pepstatin analogues: synthesis and pepsin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Effects of phosphoramidon and pepstatin A on the secretion of endothelin-1 and big endothelin-1 by human umbilical vein endothelial cells: measurement by two-site enzyme-linked immunosorbent assays

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Evidence for the role of a cathepsin D-like activity in the release of Gal beta 1-4GlcNAc alpha 2-6sialyltransferase from rat and mouse liver in whole-cell systems

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

In vitro studies of gastric juice in patients with food-cobalamin malabsorption

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Characterization of fluids from the stomach and proximal jejunum in men and women.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2897%2900204-6

7 January 2021

10.1016/S0168-3659(97)00204-6

Identifiers

DOI

1 reference

5 February 2018

PubMed ID

9685931

1 reference

5 February 2018