(Q47779111)

5 February 2018

title

Structural modification of an orally active thrombin inhibitor, LB30057: replacement of the D-pocket-binding naphthyl moiety (English)

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5 February 2018

author name string

Lee K

1

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5 February 2018

Hwang SY

2

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5 February 2018

Hong S

3

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5 February 2018

Hong CY

4

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5 February 2018

Lee CS

5

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5 February 2018

Shin Y

6

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5 February 2018

Kim S

7

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5 February 2018

Yun M

8

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5 February 2018

Yoo YJ

9

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5 February 2018

Kang M

10

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5 February 2018

Oh YS

11

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5 February 2018

language of work or name

English

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publication date

1 June 1998

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5 February 2018

Bioorganic & Medicinal Chemistry

published in

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5 February 2018

volume

6

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5 February 2018

issue

6

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5 February 2018

page(s)

869-876

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5 February 2018

Thrombin inhibitors A new generation of antithrombotics

cites work

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Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

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Thrombin active site inhibitors

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Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

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7 January 2021

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

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7 January 2021

Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group

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7 January 2021

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position

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7 January 2021

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation

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7 January 2021

Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine

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7 January 2021

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy

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7 January 2021

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

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7 January 2021

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

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7 January 2021

Challenges in the development of orally bioavailable thrombin active site inhibitors

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7 January 2021

N alpha-arylsulfonyl-omega-(4-amidinophenyl)-alpha-aminoalkylcarboxylic acid amides--novel selective inhibitors of thrombin

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7 January 2021

Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N alpha-substituted L-arginine

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7 January 2021

Thrombin inhibitors. 2. Amide derivatives of N alpha-substituted L-arginine

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7 January 2021

Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group

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7 January 2021

A novel one-step purification of human α-thrombin after direct activation of crude prothrombin enriched from plasma

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7 January 2021

The determination of enzyme inhibitor constants

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7 January 2021

10.1016/S0968-0896(98)00044-3

Identifiers

DOI

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5 February 2018

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5 February 2018