(Q47796455)

5 February 2018

title

Pharmacophore and receptor models for neurokinin receptors (English)

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5 February 2018

author name string

Anders Poulsen

1

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5 February 2018

Berith Bjørnholm

2

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5 February 2018

Klaus Gundertofte

3

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Irina D Pogozheva

4

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Tommy Liljefors

5

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5 February 2018

publication date

1 November 2003

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5 February 2018

Journal of Computer - Aided Molecular Design

published in

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5 February 2018

volume

17

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issue

11

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5 February 2018

page(s)

765-783

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5 February 2018

https://scigraph.springernature.com/pub.10.1023/b:jcam.0000017497.58165.d8

exact match

0 references

cites work

New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists

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12 December 2020

Parallel-compound synthesis: methodology for accelerating drug discovery

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12 December 2020

Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists

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12 December 2020

Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities

1 reference

12 December 2020

Combined NK1 and NK2 tachykinin receptor antagonists: synthesis and structure-activity relationships of novel oxazolidine analogues

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12 December 2020

Conformational energy penalties of protein-bound ligands

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12 December 2020

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

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12 December 2020

Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA

1 reference

12 December 2020

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

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12 December 2020

High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template

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12 December 2020

Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis

1 reference

12 December 2020

Spatial requirements of the antagonist binding site of the NK2 receptor.

1 reference

12 December 2020

Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides

1 reference

12 December 2020

Connectivity and orientation of the seven helical bundle in the tachykinin NK-1 receptor probed by zinc site engineering

1 reference

12 December 2020

GPCRDB: an information system for G protein-coupled receptors

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12 December 2020

A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes

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12 December 2020

Spiro-substituted piperidines as neurokinin receptor antagonists. II. Syntheses and NK2 receptor-antagonistic activities of N-[2-aryl-4-(spiro-substituted piperidin-1'-yl)butyl]carboxamides

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12 December 2020

Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors

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12 December 2020

Receptors and antagonists for substance P and related peptides

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12 December 2020

Effect of single point mutations of the human tachykinin NK1 receptor on antagonist affinity

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12 December 2020

The neurokinin-1 and neurokinin-2 receptor binding sites of MDL103,392 differ.

1 reference

12 December 2020

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

12 December 2020

The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

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12 December 2020

The role of histidine 265 in antagonist binding to the neurokinin-1 receptor.

1 reference

12 December 2020

Arrangement of rhodopsin transmembrane α-helices

1 reference

12 December 2020

Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists

1 reference

12 December 2020

Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor

1 reference

12 December 2020

Identification of residues involved in ligand binding to the neurokinin-2 receptor

1 reference

12 December 2020

Spiro-substituted piperidines as neurokinin receptor antagonists. I. Design and synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro [isobenzofuran-1(3H),4'piperidin]-1'-yl)butyl]-N-methylbenzamide, YM-35375, as a new lead compound for novel neurok

1 reference

12 December 2020

10.1023/B:JCAM.0000017497.58165.D8

Identifiers

DOI

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5 February 2018

journals/jcamd/PoulsenBGPL03

DBLP publication ID

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DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

1047054598

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5 February 2018