(Q47825778)

English

A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

scientific article published in February 1998

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scholarly article

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum. (English)

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

0 references

Toxoplasma gondii

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Plasmodium falciparum

1 reference

based on heuristic

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author name string

Reynolds MG

1

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

Roos DS

2

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

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publication date

1 February 1998

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

Journal of Biological Chemistry

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Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

273

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

6

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

3461-3469

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

Progress in taxonomy of the Apicomplexan protozoa

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Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group

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Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

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Thymidylate synthase-dihydrofolate reductase in protozoa

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Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.

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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

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Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

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Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine

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Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum.

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Dihydrofolate reductase mutations and chromosomal changes associated with pyrimethamine resistance of Plasmodium falciparum

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Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

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Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

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The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

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Pyrimethamine resistant mutations in Plasmodium falciparum

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The dihydrofolate reductase domain of rodent malarias: point mutations and pyrimethamine resistance.

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Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

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Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy.

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Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum.

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Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli

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Purification and characterization of dihydrofolate reductase of Plasmodium falciparum expressed by a synthetic gene in Escherichia coli.

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Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

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21 January 2018

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

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Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructs

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Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

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Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii.

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21 January 2018

Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement

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Specific Labeling of IntracellularToxoplasma gondiiwith Uracil*

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

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Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues

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Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

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In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii

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Pyrimidine Synthesis by Intracellular Toxoplasma gondii

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Pyrimidine salvage pathways in Toxoplasma gondii

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Identifiers

10.1074/JBC.273.6.3461

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/9452469

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