(Q47850639)

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Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

Plasmodium falciparum

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Flemming Steen Jørgensen

3

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

author name string

Lemcke T

1

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

Christensen IT

2

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

language of work or name

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publication date

1 June 1999

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

7

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

6

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

1003-1011

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

1 reference

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Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

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Protein sequence database

1 reference

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Crystal structure of human dihydrofolate reductase complexed with folate

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Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

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Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate

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The Protein Data Bank: a computer-based archival file for macromolecular structures

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Molecular mechanics calculations of proteins. Comparison of different energy minimization strategies.

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AMBER: Assisted model building with energy refinement. A general program for modeling molecules and their interactions

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Stereochemical quality of protein structure coordinates

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Recognition of errors in three-dimensional structures of proteins

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New hydrogen-bond potentials for use in determining energetically favorable binding sites on molecules of known structure

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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Comparative modeling methods: application to the family of the mammalian serine proteases

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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

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Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis

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Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi

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Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

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Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

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Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis

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Molecular structure of leucine aminopeptidase at 2.7-A resolution

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The NADPH binding site on beef liver catalase

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Identifiers

10.1016/S0968-0896(99)00018-8

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/10428368

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