(Q47858719)

6 February 2018

title

Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering (English)

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6 February 2018

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mesenchymal stem cell

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3

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6 February 2018

author name string

Niamh Fahy

series ordinal

1

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6 February 2018

Mauro Alini

series ordinal

2

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6 February 2018

publication date

1 August 2017

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6 February 2018

Journal of Orthopaedic Research

published in

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6 February 2018

The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.

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The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

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Effect of compressive loading on chondrocyte differentiation in agarose cultures of chick limb-bud cells.

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Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta

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Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes

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THE CHONDROCYTE: A CELL UNDER PRESSURE

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Mechanical and physiochemical determinants of the chondrocyte biosynthetic response

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Proteomic analysis of chondrocytes exposed to pressure

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Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.

21 January 2018

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Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes

21 January 2018

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Enhanced matrix synthesis in de novo, scaffold free cartilage-like tissue subjected to compression and shear.

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Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage

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Exercise protects against articular cartilage degeneration in the hamster.

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Exercise-driven metabolic pathways in healthy cartilage

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Osteoarthritis: epidemiology

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Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage

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The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage

21 January 2018

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Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants

21 January 2018

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In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae

21 January 2018

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JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation

21 January 2018

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Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling

21 January 2018

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Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage

21 January 2018

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Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation

21 January 2018

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

21 January 2018

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Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation

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Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture

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Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses

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Multilineage potential of adult human mesenchymal stem cells

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Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells

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Mesenchymal stem cells as trophic mediators

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Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture

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Cells and secretome--towards endogenous cell re-activation for cartilage repair.

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Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study

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Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration

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Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.

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Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial

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Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.

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In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.

21 January 2018

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Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor

21 January 2018

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Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

21 January 2018

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Characterization of type I receptors for transforming growth factor-beta and activin

21 January 2018

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Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors

21 January 2018

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

21 January 2018

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Sox9 is required for cartilage formation

21 January 2018

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SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

21 January 2018

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TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

21 January 2018

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Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.

21 January 2018

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Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

21 January 2018

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Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-β signaling

21 January 2018

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Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling.

21 January 2018

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Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage.

21 January 2018

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Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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MicroRNAs modulate hematopoietic lineage differentiation

21 January 2018

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Prediction of mammalian microRNA targets

21 January 2018

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Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

21 January 2018

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microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9

21 January 2018

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Silencing of anti-chondrogenic microRNA-221 in human mesenchymal stem cells promotes cartilage repair in vivo

21 January 2018

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Spontaneous In Vivo Chondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells by Blocking Vascular Endothelial Growth Factor Signaling.

21 January 2018

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Mechanical regulation of chondrogenesis.

21 January 2018

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Cyclic hydrostatic pressure promotes a stable cartilage phenotype and enhances the functional development of cartilaginous grafts engineered using multipotent stromal cells isolated from bone marrow and infrapatellar fat pad.

21 January 2018

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Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro.

21 January 2018

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Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro.

21 January 2018

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Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading.

21 January 2018

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Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines

21 January 2018

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An electromagnetic compressive force by cell exciter stimulates chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.

21 January 2018

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Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading.

21 January 2018

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Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells

21 January 2018

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The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells.

21 January 2018

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Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels

21 January 2018

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Physical stimulation of chondrogenic cells in vitro: a review

21 January 2018

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Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-beta pathway

21 January 2018

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Human Articular Cartilage Progenitor Cells Are Responsive to Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone-Morphogenetic Protein 2

21 January 2018

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Making sense of latent TGFbeta activation

21 January 2018

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Bone marrow-derived mesenchymal stem cells become antiangiogenic when chondrogenically or osteogenically differentiated: implications for bone and cartilage tissue engineering

21 January 2018

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Gene and protein expression profile of naive and osteo-chondrogenically differentiated rat bone marrow-derived mesenchymal progenitor cells

21 January 2018

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Secretome analysis of human mesenchymal stem cells undergoing chondrogenic differentiation.

21 January 2018

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Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1/CXCR4 axis via MAPK signaling pathways.

21 January 2018

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Mesenchymal stem cells regulate angiogenesis according to their mechanical environment.

21 January 2018

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Mechanical stretch endows mesenchymal stem cells stronger angiogenic and anti-apoptotic capacities via NFκB activation.

21 January 2018

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Matrix composition and mechanics direct proangiogenic signaling from mesenchymal stem cells.

21 January 2018

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 January 2018

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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

21 January 2018

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The effects of cyclic hydrostatic pressure on chondrogenesis and viability of human adipose- and bone marrow-derived mesenchymal stem cells in three-dimensional agarose constructs

21 January 2018

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Functional differences between mesenchymal stem cell populations are reflected by their transcriptome.

21 January 2018

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Effect of physical activity on articular knee joint structures in community-based adults

21 January 2018

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The Response of Bone Marrow-Derived Mesenchymal Stem Cells to Dynamic Compression Following TGF-β3 Induced Chondrogenic Differentiation

21 January 2018

1 reference

Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses

21 January 2018

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1053/JVET.1999.0242

Identifiers

DOI

10.1002/JOR.23670

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6 February 2018

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6 February 2018