(Q48004003)

7 February 2018

title

Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements (English)

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7 February 2018

author name string

W S Varade

1

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7 February 2018

J A Carnahan

2

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7 February 2018

P D Kingsley

3

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7 February 2018

R A Insel

4

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7 February 2018

publication date

1 February 1998

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7 February 2018

published in

Immunology

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7 February 2018

volume

93

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7 February 2018

issue

2

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7 February 2018

page(s)

171-176

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7 February 2018

The role of somatic hypermutation in the generation of antibody diversity

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Somatic hypermutation of immunoglobulin genes

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Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Bias in somatic hypermutation of human VH genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Human splenic IgM immunoglobulin transcripts are mutated at high frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Expressed human immunoglobulin kappa genes and their hypermutation

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Early restriction of the human antibody repertoire.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

The human immunoglobulin VH repertoire

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

High-frequency representation of a single VH gene in the expressed human B cell repertoire

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.1998.00427.X

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

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Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution

21 January 2018

1 reference

12 December 2020

Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire.

1 reference

12 December 2020

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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12 December 2020

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

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12 December 2020

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

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12 December 2020

Patterns of somatic mutations in immunoglobulin variable genes

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12 December 2020

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells

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12 December 2020

Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways

1 reference

12 December 2020

10.1046/J.1365-2567.1998.00427.X

Identifiers

DOI

1 reference

7 February 2018

1 reference

7 February 2018