(Q48047088)

English

Engineering of porcine pepsin. Alteration of S1 substrate specificity of pepsin to those of fungal aspartic proteinases by site-directed mutagenesis.

scientific article published in July 1997

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9228062%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Engineering of porcine pepsin. Alteration of S1 substrate specificity of pepsin to those of fungal aspartic proteinases by site-directed mutagenesis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9228062%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Takahiro Shintani

1

1 reference

Europe PubMed Central

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4 November 2019

author name string

K Nomura

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9228062%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

E Ichishima

3

1 reference

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4 November 2019

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publication date

1 July 1997

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4 November 2019

Journal of Biological Chemistry

1 reference

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4 November 2019

272

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4 November 2019

30

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4 November 2019

18855-18861

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4 November 2019

describes a project that uses

site-directed mutagenesis

1 reference

based on heuristic

inferred from title

Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution

1 reference

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21 January 2018

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design

1 reference

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21 January 2018

X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins

1 reference

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21 January 2018

Structure and refinement of penicillopepsin at 1.8 Å resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Crystal structure of human pepsin and its complex with pepstatin

1 reference

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21 January 2018

X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen

1 reference

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21 January 2018

On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues

1 reference

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21 January 2018

X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action

1 reference

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21 January 2018

X-ray studies of aspartic proteinase-statine inhibitor complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Engineering enzyme subsite specificity: preparation, kinetic characterization, and X-ray analysis at 2.0-A resolution of Val111Phe site-mutated calf chymosin

1 reference

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21 January 2018

Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite.

1 reference

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21 January 2018

Primary structure of aspergillopepsin I deduced from nucleotide sequence of the gene and aspartic acid-76 is an essential active site of the enzyme for trypsinogen activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Characterization of the S1 subsite specificity of aspergillopepsin I by site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Comparative specificity of microbial acid proteinases for synthetic peptides. III. Relationship with their trypsinogen activating ability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Modified acid guanidinium thiocyanate-phenol-chloroform RNA extraction method which greatly reduces DNA contamination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

A systematic series of synthetic chromophoric substrates for aspartic proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

A new chromophoric substrate for penicillopepsin and other fungal aspartic proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Amino-acid sequence of porcine pepsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Nucleotide sequence and expression in Escherichia coli of cDNA of swine pepsinogen: involvement of the amino-terminal portion of the activation peptide segment in restoration of the functional protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Electrospray mass spectrometric evidence for the occurrence of two major variants in native pig pepsin A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Four classes of beta-hairpins in proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Aspartic proteinases and their inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Alteration of catalytic properties of chymosin by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

Secretion and maturation study of endothiapepsin in Saccharomyces cerevisiae. A first step toward improving its substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

[On the activation of bovine trypsinogen by a crystallized protease from Aspergillus saitoi]

1 reference

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21 January 2018

The Mechanism of Activation of Trypsinogen. The Role of the Four N-Terminal Aspartyl Residues

1 reference

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21 January 2018

Calculation of protein conformation from circular dichroism

1 reference

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21 January 2018

Occurrence of two different pathways in the activation of porcine pepsinogen to pepsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.30.18855

21 January 2018

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