(Q48110906)

8 February 2018

http://europepmc.org/abstract/MED/29397398

title

Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles (English)

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8 February 2018

http://europepmc.org/abstract/MED/29397398

author

Himanshu Pandey

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Larisa Gheber

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Sudhir Kumar Singh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jawdat Al-Bassam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

3 February 2018

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8 February 2018

http://europepmc.org/abstract/MED/29397398

published in

Cellular and Molecular Life Sciences

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

75

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1757-1771

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29397398%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

12 December 2020

Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly

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12 December 2020

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12 December 2020

Kinetochore microtubules in PTK cells

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12 December 2020

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12 December 2020

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

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12 December 2020

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies

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12 December 2020

Mitosis in the fission yeast Schizosaccharomyces pombe: a comparative study with light and electron microscopy

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12 December 2020

Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic-mutant Saccharomyces cerevisiae

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12 December 2020

Dynamic instability of microtubule growth

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12 December 2020

Highly processive microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains

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12 December 2020

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

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12 December 2020

Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle

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12 December 2020

Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation

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12 December 2020

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

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12 December 2020

The kinesin-like protein KLP61F is essential for mitosis in Drosophila

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12 December 2020

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation

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12 December 2020

Disruption of mitotic spindle orientation in a yeast dynein mutant

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12 December 2020

Interpolar spindle microtubules in PTK cells

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12 December 2020

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast

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12 December 2020

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12 December 2020

Motor proteins 1: kinesins

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12 December 2020

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

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12 December 2020

Crystal structure of the motor domain of the kinesin-related motor ncd.

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12 December 2020

Going mobile: microtubule motors and chromosome segregation

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12 December 2020

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150

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12 December 2020

Reversal in the direction of movement of a molecular motor

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12 December 2020

The crystal structure of dimeric kinesin and implications for microtubule-dependent motility

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12 December 2020

Kinesin and dynein superfamily proteins in organelle transport and cell division.

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12 December 2020

Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins

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12 December 2020

Dynein and dynein-related genes

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12 December 2020

Determinants of kinesin motor polarity.

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12 December 2020

Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast

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12 December 2020

The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain.

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12 December 2020

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

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12 December 2020

Motile properties of the kinesin-related Cin8p spindle motor extracted from Saccharomyces cerevisiae cells

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12 December 2020

Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila

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12 December 2020

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12 December 2020

Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

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12 December 2020

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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12 December 2020

A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe

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12 December 2020

The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae

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12 December 2020

Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion

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12 December 2020

Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos

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12 December 2020

Conformational changes during kinesin motility.

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12 December 2020

Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

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12 December 2020

Cytoplasmic dynein as a facilitator of nuclear envelope breakdown

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12 December 2020

Directionality and processivity of molecular motors.

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12 December 2020

Motor proteins of the kinesin superfamily: structure and mechanism

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12 December 2020

Directionality of kinesin motors.

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12 December 2020

A force balance model of early spindle pole separation in Drosophila embryos.

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12 December 2020

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

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12 December 2020

Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning

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12 December 2020

The distribution of active force generators controls mitotic spindle position

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12 December 2020

Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics

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12 December 2020

Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes

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12 December 2020

UCSF Chimera--a visualization system for exploratory research and analysis

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12 December 2020

Kinesin transports RNA: isolation and characterization of an RNA-transporting granule

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12 December 2020

Differential effects of monastrol in two human cell lines

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12 December 2020

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

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12 December 2020

At the interface between signaling and executing anaphase--Cdc14 and the FEAR network

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12 December 2020

Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit

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12 December 2020

Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongation

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12 December 2020

Spindle microtubules in flux.

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12 December 2020

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

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12 December 2020

Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells

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12 December 2020

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

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12 December 2020

Analysis of kinesin motor function at budding yeast kinetochores.

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12 December 2020

Homotetrameric form of Cin8p, a Saccharomyces cerevisiae kinesin-5 motor, is essential for its in vivo function

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12 December 2020

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

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12 December 2020

Dynein participates in chromosome segregation in fission yeast.

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12 December 2020

Kinesin-5 acts as a brake in anaphase spindle elongation

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12 December 2020

Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array

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12 December 2020

Force generation in kinesin hinges on cover-neck bundle formation

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12 December 2020

Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.

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12 December 2020

Microtubule cross-linking triggers the directional motility of kinesin-5

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12 December 2020

Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules

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12 December 2020

Kinesin's cover-neck bundle folds forward to generate force

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12 December 2020

The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations

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12 December 2020

Kinesin-5 is essential for growth-cone turning

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12 December 2020

Mid-anaphase arrest in S. cerevisiae cells eliminated for the function of Cin8 and dynein

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12 December 2020

Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis

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12 December 2020

Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation

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12 December 2020

Motile microtubule crosslinkers require distinct dynamic properties for correct functioning during spindle organization in Xenopus egg extract

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12 December 2020

The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation

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12 December 2020

Regulation of centrosome separation in yeast and vertebrates: common threads

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12 December 2020

Force and length in the mitotic spindle

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12 December 2020

Mitotic functions of kinesin-5.

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12 December 2020

The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera

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12 December 2020

B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast

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12 December 2020

A membranous spindle matrix orchestrates cell division

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12 December 2020

Kip3, the yeast kinesin-8, is required for clustering of kinetochores at metaphase

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12 December 2020

Mechanisms of centrosome separation and bipolar spindle assembly

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12 December 2020

A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

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12 December 2020

Directional switching of the kinesin Cin8 through motor coupling

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12 December 2020

Phospho-regulation of kinesin-5 during anaphase spindle elongation.

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12 December 2020

Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo

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12 December 2020

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

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12 December 2020

Interhead tension determines processivity across diverse N-terminal kinesins

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12 December 2020

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12 December 2020

Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry.

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12 December 2020

Anaphase B precedes anaphase A in the mouse egg.

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12 December 2020

Coupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machines

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12 December 2020

Mitotic spindle form and function

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12 December 2020

Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5

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12 December 2020

Regulation of bi-directional movement of single kinesin-5 Cin8 molecules

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12 December 2020

Neck-linker length dependence of processive Kinesin-5 motility.

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12 December 2020

The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

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12 December 2020

The bipolar assembly domain of the mitotic motor kinesin-5

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12 December 2020

The cell biology of open and closed mitosis

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12 December 2020

New insights into the mechanism of force generation by kinesin-5 molecular motors.

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12 December 2020

Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo

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12 December 2020

Structure of a kinesin-tubulin complex and implications for kinesin motility

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12 December 2020

Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly

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12 December 2020

Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.

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12 December 2020

Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.

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12 December 2020

Eg5 restricts anaphase B spindle elongation in mammalian cells

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12 December 2020

Bidirectional motility of the fission yeast kinesin-5, Cut7.

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12 December 2020

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

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12 December 2020

Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

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12 December 2020

Deciphering the evolutionary history of open and closed mitosis

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12 December 2020

Sharpening the anaphase switch.

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12 December 2020

Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality

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12 December 2020

Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol

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12 December 2020

A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes

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12 December 2020

Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism

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12 December 2020

Kinesin-5 is a microtubule polymerase

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12 December 2020

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

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12 December 2020

Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth

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12 December 2020

The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.

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12 December 2020

Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7.

1 reference

12 December 2020

Review: Mechanochemistry of the kinesin-1 ATPase

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12 December 2020

Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain

1 reference

12 December 2020

Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.

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12 December 2020

Spindle Assembly Checkpoint as a Potential Target in Colorectal Cancer: Current Status and Future Perspectives.

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12 December 2020

Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

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12 December 2020

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12 December 2020

Microtubule-associated proteins, Bik1 and Bim1, are required for faithful partitioning of the endogenous 2 micron plasmids in budding yeast

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12 December 2020

The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

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12 December 2020

A potential physiological role for bi-directional motility and motor clustering of mitotic kinesin-5 Cin8 in yeast mitosis.

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12 December 2020

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.

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12 December 2020

Metaphase Spindle Assembly

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12 December 2020

Mitotic spindle assembly in animal cells: a fine balancing act.

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12 December 2020

Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles

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12 December 2020

Embedding dual function into molecular motors through collective motion

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12 December 2020

Moonlighting Motors: Kinesin, Dynein, and Cell Polarity

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12 December 2020

Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase

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12 December 2020

Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles

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12 December 2020

Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines

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12 December 2020

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

1 reference

12 December 2020

The 2 micron plasmid: a selfish genetic element with an optimized survival strategy within Saccharomyces cerevisiae

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12 December 2020

The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner

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12 December 2020

Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement.

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12 December 2020

10.1007/S00018-018-2754-7

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