(Q48170385)

9 February 2018

title

A somatically mutated V kappa IV gene encoding a human rheumatoid factor light chain. (English)

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9 February 2018

author

Ralf Küppers

series ordinal

2

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9 February 2018

author name string

Gause A

series ordinal

1

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9 February 2018

Mierau R

series ordinal

3

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9 February 2018

publication date

1 June 1992

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9 February 2018

Clinical and Experimental Immunology

published in

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9 February 2018

volume

88

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9 February 2018

issue

3

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9 February 2018

page(s)

430-434

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9 February 2018

A human monoclonal IgA rheumatoid factor using the VkIV light chain gene.

cites work

1 reference

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A new subgroup of the Kappa chain variable region associated with anti-Pr cold agglutinins

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Rheumatoid factors and complex formation. The role of light-chain framework sequences and glycosylation

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Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

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Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor

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Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes

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New roles for rheumatoid factor

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The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc

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12 December 2020

The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire

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12 December 2020

Occurrence of two germline-related rheumatoid factor idiotypes in rheumatoid arthritis and in non-rheumatoid seropositive individuals

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12 December 2020

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response

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Probing of the rheumatoid factor (RF) V gene repertoire in rheumatoid arthritis (RA) by hybridoma clones

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Evidence for locally synthesized and clonally restricted immunoglobulin in the synovial fluid from rheumatoid arthritis patients

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12 December 2020

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

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12 December 2020

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

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12 December 2020

Detection of a unique human V kappa IV germline gene by a cloned cDNA probe

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Multiple mutations in the variable region of the kappa light chains of three monoclonal human IgM with anti-myelin-associated glycoprotein activity

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Single-stranded DNA 'blue' T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering.

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The role of clonal selection and somatic mutation in autoimmunity

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Restricted heterogeneity of polyclonal rheumatoid factors

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12 December 2020

Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross-reactive idiotopes and expression of VH and Vϰ subgroups

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Dissociation of expression of two rheumatoid factor cross-reactive kappa L chain idiotopes in rheumatoid arthritis

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12 December 2020

Monoclonal antibody 6b6.6 defines a cross-reactive kappa light chain idiotope on human monoclonal and polyclonal rheumatoid factors

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12 December 2020

Idiotypic and molecular characterization of human rheumatoid factors.

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12 December 2020

Qualitative and quantitative expression of VHI associated cross reactive idiotopes within IgM rheumatoid factor from patients with early synovitis

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Three M components IgA lambda, + IgG kappa n + IgG kappa h in one patient. II. Structurally different kappa n and kappa h chains associated with H(gamma) chains sharing idiotypic determinants

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Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

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12 December 2020

10.1111/J.1365-2249.1992.TB06467.X

Identifiers

DOI

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9 February 2018

0 references

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9 February 2018