(Q48187234)

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Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements.

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28 March 2020

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements (English)

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28 March 2020

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chronic lymphocytic leukemia

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Achilles Anagnostopoulos

9

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28 March 2020

Elisavet Vlachonikola

2

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28 March 2020

Nicos Maglaveras

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28 March 2020

Ioanna Chouvarda

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28 March 2020

author name string

A Vardi

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M Karypidou

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E Stalika

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V Bikos

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K Gemenetzi

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C Maramis

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A Siorenta

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S Pospisilova

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K Stamatopoulos

13

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A Hadzidimitriou

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28 March 2020

publication date

25 November 2016

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31

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1555-1561

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7

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28 March 2020

https://scigraph.springernature.com/pub.10.1038/leu.2016.362

0 references

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.362

21 January 2018

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/27904140

12 December 2020

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10.1038/LEU.2016.362

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Europe PubMed Central

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28 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904140%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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