(Q48213324)

9 February 2018

title

P-Glycoprotein attenuates brain uptake of substrates after nasal instillation. (English)

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9 February 2018

author name string

Candace L Graff

series ordinal

1

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9 February 2018

Gary M Pollack

series ordinal

2

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9 February 2018

publication date

1 August 2003

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9 February 2018

published in

Pharmaceutical Research

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9 February 2018

volume

20

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9 February 2018

issue

8

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9 February 2018

page(s)

1225-1230

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9 February 2018

Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal

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Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats

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Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa

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Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats.

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FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

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Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay.

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Spread of MHV-JHM from nasal cavity to white matter of spinal cord. Transneuronal movement and involvement of astrocytes.

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Antiretroviral drugs and the central nervous system.

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The Transport of a Drug to the Cerebrospinal Fluid Directly from the Nasal Cavity: The Relation to the Lipophilicity of the Drug

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12 December 2020

Transport of drugs from the nasal cavity to the central nervous system

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12 December 2020

Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.

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12 December 2020

Nasal route for direct delivery of solutes to the central nervous system: fact or fiction?

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12 December 2020

Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier

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12 December 2020

Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa

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12 December 2020

Intranasal drug delivery

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12 December 2020

Intranasal delivery could be used to administer drugs directly to the brain.

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12 December 2020

Quantitative analysis of the olfactory pathway for drug delivery to the brain

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12 December 2020

Transfer of dopamine in the olfactory pathway following nasal administration in mice

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12 December 2020

Nasal absorption of testosterone in rats

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12 December 2020

Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs

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12 December 2020

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

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12 December 2020

Direct nose-brain transport of benzoylecgonine following intranasal administration in rats

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12 December 2020

Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds

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12 December 2020

Identifiers

DOI

10.1023/A:1025053115583

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9 February 2018

PubMed ID

12948020

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9 February 2018