(Q48225815)

English

A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers.

scientific article published on 17 February 2017

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28210006%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers (English)

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3 April 2020

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Masahiro Kawahara

2

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3 April 2020

Akifumi Takaori-Kondo

14

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3 April 2020

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N Sugino

1

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3 April 2020

G Tatsumi

3

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3 April 2020

A Kanai

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3 April 2020

H Matsui

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3 April 2020

R Yamamoto

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3 April 2020

Y Nagai

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3 April 2020

S Fujii

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3 April 2020

Y Shimazu

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3 April 2020

M Hishizawa

10

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3 April 2020

T Inaba

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3 April 2020

A Andoh

12

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3 April 2020

T Suzuki

13

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3 April 2020

publication date

17 February 2017

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3 April 2020

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3 April 2020

31

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3 April 2020

11

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3 April 2020

2303-2314

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3 April 2020

https://scigraph.springernature.com/pub.10.1038/leu.2017.59

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

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Nucleosome dynamics define transcriptional enhancers

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Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

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Environment drives selection and function of enhancers controlling tissue-specific macrophage identities

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

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Identifiers

10.1038/LEU.2017.59

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28210006%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28210006%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

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