(Q4822789)

English

Toll like receptor 7

mammalian protein found in Homo sapiens

TLR7
toll-like receptor 7-like
uniprot:Q9NYK1
toll-like receptor 7

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

toll-like receptor

0 references

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Toll-like receptor 7

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

BspA type Leucine rich repeat region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transmembrane signaling receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

double-stranded RNA binding

determination method

1 reference

8 April 2019

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

single-stranded RNA binding

determination method

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

single-stranded RNA binding

determination method

pattern recognition receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

determination method

receptor complex

determination method

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

phagocytic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

determination method

endoplasmic reticulum

determination method

plasma membrane

determination method

1 reference

27 March 2018

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

endolysosome membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

endosome membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

biological process

I-kappaB phosphorylation

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

positive regulation of inflammatory response

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

toll-like receptor 9 signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

positive regulation of interleukin-8 production

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

defense response to virus

determination method

3 references

27 March 2018

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

microglial cell activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

positive regulation of interleukin-6 production

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

MyD88-dependent toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

positive regulation of chemokine production

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

immune response

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

determination method

toll-like receptor 7 signaling pathway

determination method

innate immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

toll-like receptor signaling pathway

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

defense response to virus

determination method

4 references

8 April 2019

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

hydroxychloroquine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL549344

Gene Atlas image

PBB GE TLR7 220146 at fs.png
732 × 530; 11 KB

0 references

BspA type Leucine rich repeat region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

cysteine-rich flanking region, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

leucine-rich repeat, typical subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Leucine-rich repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYK1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000370034

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370034

1 reference

Freebase Data Dumps

publication date

28 October 2013

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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