(Q48279768)

English

The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway.

scientific article published in February 2007

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Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/17287504

The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

0 references

Parkinson's disease

1 reference

based on heuristic

inferred from title

parkinsonian syndrome

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

Claudio Trapella

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

author name string

Michele Morari

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

language of work or name

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publication date

1 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/17287504

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

27

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

1297-1307

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6673573/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa motor complications in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin/orphanin FQ receptors modulate glutamate extracellular levels in the substantia nigra pars reticulata. A microdialysis study in the awake freely moving rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct forelimb and hind limb stepping impairments in unilateral dopamine-depleted rats: use of the rotorod as a method for the qualitative analysis of skilled walking

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: implications for Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence for a concordant response of terminal and dendritic dopamine release during intranigral infusion of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose methamphetamine acutely activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different responsiveness of striatonigral and striatopallidal neurons to L-DOPA after a subchronic intermittent L-DOPA treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consequences of partial and severe dopaminergic lesion on basal ganglia oscillatory activity and akinesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primate models of movement disorders of basal ganglia origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rat ventromedial thalamic nucleus and motor control: role of N-methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The catalepsy test: its ups and downs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing roles of dopamine D1 and D2 receptors in nigral gamma-[3H]aminobutyric acid release?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thalamus as a relay station for catalepsy and rigidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the ventromedial thalamic nucleus in the catalepsy evoked from the substantia nigra pars reticulata in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous dopamine can modulate inhibition of substantia nigra pars reticulata neurons elicited by GABA iontophoresis or striatal stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disinhibition as a basic process in the expression of striatal functions. II. The striato-nigral influence on thalamocortical cells of the ventromedial thalamic nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a GABAergic projection from the substantia nigra to the ventromedial thalamus and to the superior colliculus of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excessive bracing reactions and their control by atropine and l-DOPA in an animal analog of parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a GABAergic nigrothalamic pathway in the rat. II. Electrophysiological studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between dopamine and gamma-aminobutyrate in the substantia nigra: implications for the striatonigral output hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of apomorphine-induced rotational behaviour by subthalamic lesion in 6-OHDA lesioned rats is associated with a normalization of firing rate and discharge pattern of pars reticulata neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA and GABAA receptor changes in the substantia nigra of the rat following quinolinic acid lesions in the striatum closely resemble Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat substantia nigra pars reticulata neurones are tonically inhibited via GABAA, but not GABAB, receptors in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional neuroanatomy of the nigrostriatal and striatonigral pathways as studied with dual probe microdialysis in the awake rat--I. Effects of perfusion with tetrodotoxin and low-calcium medium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of a rodent model of Parkinson's Disease: evidence of a therapeutic window for oral Sinemet

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17287504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4346-06.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673573&resulttype=core&format=json

11 May 2020

ResearchGate publication ID

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