(Q48349780)

10 February 2018

title

Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. (English)

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10 February 2018

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12

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author name string

Simons ER

1

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10 February 2018

Marshall DC

2

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10 February 2018

Long HJ

3

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10 February 2018

Otto K

4

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10 February 2018

Billingslea A

5

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10 February 2018

Tibbles H

6

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10 February 2018

Wells J

7

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10 February 2018

Eisenhauer P

8

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10 February 2018

Fine RE

9

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Cribbs DH

10

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Davies TA

11

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publication date

1 September 1998

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10 February 2018

published in

Amyloid

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10 February 2018

volume

5

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10 February 2018

issue

3

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10 February 2018

page(s)

153-162

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10 February 2018

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

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Generation of amyloid beta protein from its precursor is sequence specific

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Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

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Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus

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A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.

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A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein.

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A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments.

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A cell culture model of the blood-brain barrier

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Amyloid beta-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders

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Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

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Activated Alzheimer disease platelets retain more beta amyloid precursor protein.

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Moderate and advanced Alzheimer's patients exhibit platelet activation differences.

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Blood brain barrier in ageing and Alzheimer's disease

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Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels

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Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor

21 January 2018

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Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity.

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Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta

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Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.

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Amyloid β-protein precursor and apolipoprotein E production in cultured cerebral endothelial cells isolated from brains of patients with neurodegenerative disorders at autopsy

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Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

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Platelets from patients with Alzheimer's disease or other dementias exhibit disease-specific and apolipoprotein E correlatable defects

21 January 2018

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Alzheimer's disease amyloid precursor protein (ApPP): proteolytic processing, secretases and βA4 amyloid production

21 January 2018

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10.3109/13506129809003841

21 January 2018

Identifiers

DOI

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10 February 2018

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10 February 2018