(Q48357599)

English

Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil

scientific article published in September 1998

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

hepatic encephalopathy

1 reference

based on heuristic

inferred from title

author name string

H P Meyer

1

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

D A Legemate

2

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

W van den Brom

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

J Rothuizen

4

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

publication date

1 September 1998

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

Metabolic Brain Disease

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

13

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

241-251

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

https://scigraph.springernature.com/pub.10.1023/a:1023228126315

0 references

Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flumazenil does not affect the increase in rat hippocampal extracellular glutamate concentration produced during thioacetamide-induced hepatic encephalopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma GABA, GABA-like activity and the brain GABA-benzodiazepine receptor complex in rats with chronic hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinities and densities of high-affinity [3H]muscimol (GABA-A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative EEG analysis and evoked potentials to measure (latent) hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the presence of a benzodiazepine receptor binding substance in cerebrospinal fluid of a rabbit model of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Endogenous" benzodiazepine activity in body fluids of patients with hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic encephalopathy and the gamma-aminobutyric-acid neurotransmitter system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic-ammonia interactions in hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased benzodiazepine-like activity is neither necessary nor sufficient to explain acute hepatic encephalopathy in the thioacetamide-treated rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of flumazenil on subclinical psychometric or neurophysiological alterations in cirrhotic patients: a double-blind placebo-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gut bacteria provide precursors of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABAergic inhibition of the pituitary release of adrenocorticotropin and alpha-melanotropin is impaired in dogs with hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Di Mascio Lecture. The allosteric modulation of GABAA receptors. Seventeen years of research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of hepatic encephalopathy by pharmacologic antagonism of the GABAA-benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful long-term treatment of portal-systemic encephalopathy by the benzodiazepine antagonist flumazenil

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive amino acids in hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurology and the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy: a double blind, randomised, placebo controlled multicentre study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic encephalopathy. Application of visual evoked responses to test hypotheses of its pathogenesis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic action of the neurosteroid pregnenolone sulfate on inhibitory transmitter release in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine receptor antagonism improves reaction time in latent hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-glutamate and gamma-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of flumazenil on the electroencephalogram of patients with portosystemic encephalopathy. Results of a double blind, randomised, placebo-controlled multicentre trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of endogenous benzodiazepine receptor ligands in brain disorders: therapeutic potential for benzodiazepine antagonists?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain gamma-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma gamma-aminobutyric acid-like activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of EEG power spectra in experimental hepatic encephalopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flumazenil therapy for hepatic encephalopathy. A double-blind cross over study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of benzodiazepine receptor ligands in hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid gamma-aminobutyric acid levels in dogs with chronic portosystemic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine receptor ligands and hepatic encephalopathy: further unfolding of the GABA story

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnostic tools for the detection of subclinical hepatic encephalopathy: comparison of standard and computerized psychometric tests with spectral-EEG.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of ligand binding to components of the GABAA receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/9804368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1023228126315

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/9804368

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