(Q48545858)

12 February 2018

title

Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5. (English)

1 reference

12 February 2018

1 reference

Glyn Thomas

1

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12 February 2018

Matthew J Killeen

2

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12 February 2018

Iman S Gurung

3

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12 February 2018

Parvez Hakim

4

1 reference

12 February 2018

Richard Balasubramaniam

5

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12 February 2018

Catharine A Goddard

6

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12 February 2018

Andrew A Grace

7

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12 February 2018

Christopher L-H Huang

8

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12 February 2018

language of work or name

English

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publication date

9 November 2006

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12 February 2018

number of pages

16

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inferred from page(s)

published in

Journal of Physiology

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12 February 2018

volume

578

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12 February 2018

issue

Pt 1

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12 February 2018

page(s)

99-114

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12 February 2018

The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion

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From pulsus to pulseless: the saga of cardiac alternans

2 November 2018

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Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome

2 November 2018

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2 November 2018

L-type calcium channels

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Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall

2 November 2018

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The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient

2 November 2018

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Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve

2 November 2018

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Molecular correlates of repolarization alternans in cardiac myocytes

2 November 2018

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Atrial fibrillation in KCNE1-null mice

2 November 2018

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Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil

2 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Spatial dispersion of repolarization is a key factor in the arrhythmogenicity of long QT syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Role of calcium cycling versus restitution in the mechanism of repolarization alternans

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

A patient with LQTS in whom verapamil administration and permanent pacemaker implantation were useful for preventing torsade de pointes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here?

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Characterization of mice with a combined suppression of I(to) and I(K,slow).

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Action potential characteristics and arrhythmogenic properties of the cardiac conduction system of the murine heart

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Congenital and acquired long QT syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Preventing ventricular fibrillation by flattening cardiac restitution

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Inner ear defects induced by null mutation of the isk gene

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

T wave alternans in idiopathic long QT syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Differential expression of Isk mRNAs in mouse tissue during development and pregnancy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Early afterdepolarization in mouse atrial fibers induced by 3.0 mM K+ and the inhibitory effects of tetrodotoxin and nifedipine.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075126

Clinical trials update: OPTIME-CHF, PRAISE-2, ALL-HAT

2 November 2018

1 reference

12 December 2020

Transgenic models in cardiac arrhythmias: how close can we get to the bedside?

1 reference

12 December 2020

In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave

1 reference

12 December 2020

Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells

1 reference

12 December 2020

Suppression of Torsades de Pointes with verapamil in patients with atrio-ventricular block

1 reference

12 December 2020

Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness

1 reference

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Contribution of L-type Ca2+ current to electrical activity in sinoatrial nodal myocytes of rabbits

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Cellular and ionic basis for T-wave alternans under long-QT conditions

1 reference

12 December 2020

Transmural dispersion in LQT3 and arrhythmogenesis

1 reference

12 December 2020

Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation

1 reference

12 December 2020

Probing the arrhythmogenic substrate

1 reference

12 December 2020

Electrical alternans and vulnerability to ventricular arrhythmias

1 reference

12 December 2020

The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns

1 reference

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Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group

1 reference

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Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: tridimensional analysis of the kinetics of cardiac repolarization

1 reference

12 December 2020

HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers

1 reference

12 December 2020

Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype

1 reference

12 December 2020

Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia

1 reference

12 December 2020

10.1113/JPHYSIOL.2006.118133

Identifiers

DOI

1 reference

12 February 2018

PMC publication ID

2075126

0 references

1 reference

12 February 2018